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NCT05405426 · ClinicalTrials.gov registry record · NA
Trial of Indication-Based Transfusion of Red Blood Cells in ECMO
A NA study of Extracorporeal Membrane Oxygenation and Red Blood Cell Transfusion, sponsored by Boston Children's Hospital.
- Active
- Registry status
- NA
- Development phase
- 228
- Enrollment target
- 20
- Study locations
NCT05405426: Active NA study of Extracorporeal Membrane Oxygenation and Red Blood Cell Transfusion, sponsored by Boston Children's Hospital.
NCT05405426 is a NA study of Extracorporeal Membrane Oxygenation and Red Blood Cell Transfusion that is active but no longer recruiting, run by Boston Children's Hospital. The registered enrollment target is 228 participants, roughly in line with the 232-participant average among 5 other Extracorporeal Membrane Oxygenation trials with a reported enrollment target. The trial reports 20 study locations across 17 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05405426, a NA study of Extracorporeal Membrane Oxygenation and Red Blood Cell Transfusion, is active but no longer recruiting, sponsored by Boston Children's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 228 participants
- Enrollment target
- 20
- Study locations
Study Summary
TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter, prospective, randomized clinical trial. The overarching goal of TITRE is to determine whether restricting red blood cell (RBC) transfusion according to an indication-based strategy for those with bleeding and/or deficit of tissue oxygen delivery, compared with transfusion based on center-specific hemoglobin or hematocrit thresholds, can reduce organ dysfunction and improve later neurodevelopment in critically ill children receiving Extracorporeal Membrane Oxygenation (ECMO) support.
Primary Outcome
The pSOFA score ranges from 0 (no organ dysfunction) through 24 (severe dysfunction in all 6 organs assessed). If death occurs during ECMO within 30 days, a score of 24 is assigned.
Conditions Studied
Interventions
- OTHER Red blood cell transfusion
Study Locations (20)
California
- Children's Hospital Los Angeles - Los Angeles
- Lucile Packard Children's Hospital - Palo Alto
Michigan
- University of Michigan Medical Center - Ann Arbor
- Children's Hospital of Michigan - Detroit
Texas
- Children's Health Dallas University of Texas Southwestern - Dallas
- Texas Children's Hospital - Baylor College of Medicine - Houston
Arizona
- Phoenix Children's Hospital - Phoenix
Arkansas
- Arkansas Children's Hospital - Little Rock
Colorado
- Children's Hospital Colorado - Aurora
Georgia
- Children's Healthcare of Atlanta - Atlanta
Illinois
- Lurie Children's Hospital - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 228 participants |
| Start Date | 2023-04-14 |
| Est. Completion | 2026-12 |
| Phase | NA |
What the registry record for NCT05405426 still lists
NCT05405426 is an interventional study that assigns participants to a tested intervention. The registered 228 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 232-participant average among 5 other Extracorporeal Membrane Oxygenation trials with a reported enrollment target.
The record links to 3 conditions, with Extracorporeal Membrane Oxygenation appearing as the primary indexed condition, and to 1 intervention - of which Red blood cell transfusion is the first listed.
NCT05405426 names 20 study sites across 17 states, led by California, Michigan, Texas.
Frequently Asked Questions
What is clinical trial NCT05405426 about?
NCT05405426 is a clinical study titled "Trial of Indication-Based Transfusion of Red Blood Cells in ECMO". TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter, prospective, randomized clinical trial. The overarching goal of TITRE is to determine whether restricting red blood cell (RBC) transfusion according to an indication-based strategy for those with bleeding and...
What is the current status of trial NCT05405426?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 228 participants. The study started on 2023-04-14. Estimated completion is 2026-12.
What conditions does trial NCT05405426 study?
This clinical trial studies the following conditions: Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion, Organ Failure, Multiple.
What interventions are being tested in trial NCT05405426?
The interventions under investigation include: Red blood cell transfusion (OTHER).
Who is sponsoring clinical trial NCT05405426?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05405426 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Colorado, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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