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NCT05208307 · ClinicalTrials.gov registry record · Phase 2
Belantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk Myeloma
A Phase 2 study of Plasma Cell Myeloma, sponsored by Emory University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 34
- Enrollment target
- 1
- Study location
NCT05208307: Recruiting Phase 2 study of Plasma Cell Myeloma, sponsored by Emory University.
NCT05208307 is a Phase 2 study of Plasma Cell Myeloma that is actively recruiting participants, run by Emory University. The registered enrollment target is 34 participants, below the 207-participant average among 32 other Plasma Cell Myeloma trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05208307, a Phase 2 study of Plasma Cell Myeloma, is actively recruiting participants, sponsored by Emory University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 34 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase II trial studies the effect of belantamab mafodotin, pomalidomide, and dexamethasone in treating patents with high-risk myeloma. Belantamab mafodotin is a monoclonal antibody, called belantamab, linked to a chemotherapy drug, called mafodotin. Belantamab is a form of targeted therapy because it attaches to specific molecules on the surface of cancer cells, known as BCMA receptors, and delivers mafodotin to kill them. Chemotherapy drugs, such as pomalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Anti-inflammatory drugs, such as dexamethasone lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Giving belantamab mafodotin, pomalidomide, and dexamethasone may kill more cancer cells.
Primary Outcome
Assessed per International Myeloma Working Group criteria (best response during maintenance therapy).
Conditions Studied
Interventions
- DRUG Dexamethasone
- DRUG Pomalidomide
- BIOLOGICAL Belantamab Mafodotin
Study Locations (1)
Georgia
- Emory University/Winship Cancer Institute - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2022-07-21 |
| Est. Completion | 2027-10-21 |
| Phase | Phase 2 |
What NCT05208307 shows while recruiting
NCT05208307 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 207-participant average among 32 other Plasma Cell Myeloma trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Plasma Cell Myeloma appearing as the primary indexed condition, and to 3 interventions - of which Dexamethasone is the first listed.
NCT05208307 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT05208307 about?
NCT05208307 is a clinical study titled "Belantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk Myeloma". This phase II trial studies the effect of belantamab mafodotin, pomalidomide, and dexamethasone in treating patents with high-risk myeloma. Belantamab mafodotin is a monoclonal antibody, called belantamab, linked to a chemotherapy drug, called mafodotin. Belantamab is a form of targeted therapy beca...
What is the current status of trial NCT05208307?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 34 participants. The study started on 2022-07-21. Estimated completion is 2027-10-21.
What conditions does trial NCT05208307 study?
This clinical trial studies the following conditions: Plasma Cell Myeloma.
What interventions are being tested in trial NCT05208307?
The interventions under investigation include: Dexamethasone (DRUG), Pomalidomide (DRUG), Belantamab Mafodotin (BIOLOGICAL).
Who is sponsoring clinical trial NCT05208307?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05208307 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Plasma Cell Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05208307's enrollment target sits among peer trials
34 23rd of 32 higher than 10 of 32 other Plasma Cell Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Plasma Cell Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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