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ClinicalTrials.gov 5 recruiting now official registry

Recurrent Plasma Cell Myeloma clinical trials

5 of 24 indexed Recurrent Plasma Cell Myeloma trials are currently recruiting.

24 US clinical trials · 5 currently recruiting

Recurrent Plasma Cell Myeloma is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is City of Hope Medical Center, running 5 of these trials.

The research picture

Recurrent Plasma Cell Myeloma has 24 registered US clinical trials, 5 of them open to new participants right now, about 21% of the total.

5
recruiting participants now
21%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
5
top sponsor: City of Hope Medical Center
Phase 113Phase 28

Active & Recent Trials

24 total, page 1 of 1

RECRUITING NA 175 participants

Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma

Roswell Park Cancer Institute

NCT05312255

RECRUITING Phase 1 127 participants

A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma

Mayo Clinic

NCT03017820

RECRUITING Phase 1 30 participants

CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma

City of Hope Medical Center

NCT03710421

RECRUITING Phase 2 29 participants

Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

City of Hope Medical Center

NCT04508790

RECRUITING Phase 1 15 participants

Radioimmunotherapy (111Indium/225Actinium-DOTA-daratumumab) for the Treatment of Relapsed/Refractory Multiple Myeloma

City of Hope Medical Center

NCT05363111

ACTIVE NOT RECRUITING 192 participants

Frequency of Cachexia in Ambulatory Cancer Patients and Psychological Burden in Patients and Their Primary Caregivers

M.D. Anderson Cancer Center

NCT04090619

ACTIVE NOT RECRUITING Phase 2 52 participants

Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refractory Multiple Myeloma

Academic and Community Cancer Research United

NCT04756401

ACTIVE NOT RECRUITING Phase 2 40 participants

Daratumumab, Bortezomib, and Dexamethasone Followed by Daratumumab, Ixazomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

M.D. Anderson Cancer Center

NCT03763162

ACTIVE NOT RECRUITING Phase 1 22 participants

Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma

Mayo Clinic

NCT04640779

ACTIVE NOT RECRUITING Phase 2 20 participants

Nivolumab for Relapsed, Refractory, or Detectable Disease Post Chimeric Antigen Receptor T-cell Treatment in Patients With Hematologic Malignancies

University of Washington

NCT04205409

ACTIVE NOT RECRUITING Phase 1 10 participants

Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial

University of Southern California

NCT05514990

ACTIVE NOT RECRUITING Phase 1 7 participants

Venetoclax and Tocilizumab for the Treatment of Patients With Relapsed or Refractory t(11;14) Multiple Myeloma

Emory University

NCT05391750

ACTIVE NOT RECRUITING Phase 1 5 participants

Genetically Engineered Cells (MUC1-Activated T-Cells) for the Treatment of MUC1 Positive Recurrent or Refractory Multiple Myeloma

Mayo Clinic

NCT05411497

ACTIVE NOT RECRUITING Phase 2 5 participants

Isatuximab, Carfilzomib, and Pomalidomide for the Treatment of Relapsed or Refractory Multiple Myeloma

OHSU Knight Cancer Institute

NCT04850599

COMPLETED Phase 2 143 participants

S1304, Carfilzomib and Dexamethasone for Treating Patients With Relapsed or Refractory Myeloma

SWOG Cancer Research Network

NCT01903811

COMPLETED Phase 2 70 participants

Ixazomib and Dexamethasone Versus Ixazomib, Dexamethasone and Lenalidomide, Randomized With NFKB2 Rearrangement

Emory University

NCT02765854

COMPLETED Phase 1 63 participants

Panobinostat and Carfilzomib in Treating Participants With Relapsed or Refractory Multiple Myeloma

M.D. Anderson Cancer Center

NCT01301807

COMPLETED Phase 1 41 participants

Dinaciclib, Bortezomib, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma

National Cancer Institute (NCI)

NCT01711528

COMPLETED Phase 1 32 participants

Ixazomib Plus Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Relapsed/Refractory Multiple Myeloma

City of Hope Medical Center

NCT02119468

COMPLETED Phase 1 28 participants

Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma

Fred Hutchinson Cancer Center

NCT03338972

COMPLETED 23 participants

Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell Therapy

University of California, San Francisco

NCT04409314

COMPLETED Phase 1 18 participants

Bortezomib, Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant For High-Risk Stage I or II Multiple Myeloma

City of Hope Medical Center

NCT01163357

COMPLETED Phase 1 11 participants

Combination Chemotherapy and Donor Stem Cell Transplant Followed by Ixazomib Citrate Maintenance Therapy in Treating Patients With Relapsed High-Risk Multiple Myeloma

OHSU Knight Cancer Institute

NCT02504359

COMPLETED Phase 2 8 participants

Ixazomib Citrate, Pomalidomide, Dexamethasone, Stem Cell Transplant in Treating Relapsed or Refractory Multiple Myeloma

Mayo Clinic

NCT03202628

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Recurrent Plasma Cell Myeloma Trial Landscape

24 indexed Recurrent Plasma Cell Myeloma studies · 5 recruiting (21%).

Phase mix: 0 late (III/IV) vs 21 early (I/II).

Top sponsor: City of Hope Medical Center (5 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Recurrent Plasma Cell Myeloma?

PlainTrial tracks 24 US clinical trials for Recurrent Plasma Cell Myeloma, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Recurrent Plasma Cell Myeloma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.