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NCT04937179 · ClinicalTrials.gov registry record · NA
The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD
A NA study, sponsored by University of Illinois at Chicago.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
NCT04937179 is a NA study that has completed, run by University of Illinois at Chicago. The registered enrollment target is 21 participants.
The verdict
NCT04937179, a NA study, has completed, sponsored by University of Illinois at Chicago.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
Study Summary
Lower limb amputation is common in the United States, with approximately 150,000 amputations annually. Most individuals walking with a prosthesis demonstrate asymmetrical loading-i.e., they favor the amputated side by placing more weight and increased ground reaction forces through the intact limb-which likely contributes to increased metabolic cost of walking. Lack of adequate muscular strength in the lower limb to attenuate these forces places increased stress on the joints, which may be displaced proximally, and may play a role in reported knee and hip pain in the intact limb. Lower limb muscle weakness following amputation has been well documented. Increasing quadriceps strength is important after an amputation because it is positively correlated with gait speed. Gait speed may also be associated with successful community mobility, which leads to improved quality of life following amputation. Individuals with amputation who resume an active lifestyle are able to maintain strength. However, these individuals represent a minority of persons with lower limb amputation; most individuals report more barriers than motivators to adopt an active lifestyle. Ischemic conditioning (IC) may strengthen leg muscles and reduce the metabolic cost of activity after amputation. In IC, the limb is exposed to brief, repeated bouts of ischemia (reduced blood flow) immediately followed by reperfusion. IC has been shown to improve muscle performance in healthy and diseased populations. IC has also been used more recently in patients with peripheral artery disease (PAD) as an intervention to improve function, such as walking ability. Acute exposure to IC increases muscle strength and activation, both in healthy, active individuals and in those with severe neuromuscular dysfunction, such as stroke survivors. IC also attenuates muscular fatigue. Increased fatigue resistance at submaximal contraction levels following IC may be due to increased neural activation of skeletal muscle. Chang
Interventions
- PROCEDURE Ischemic Conditioning Low - Sham Comparator
- PROCEDURE Ischemic Conditioning High - Active Comparator
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2022-07-01 |
| Est. Completion | 2024-12-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04937179
The ClinicalTrials.gov registry entry for NCT04937179 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Illinois at Chicago, which has 430 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Ischemic Conditioning Low - Sham Comparator is the first listed.
NCT04937179 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04937179 about?
NCT04937179 is a clinical study titled "The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD". Lower limb amputation is common in the United States, with approximately 150,000 amputations annually. Most individuals walking with a prosthesis demonstrate asymmetrical loading-i.e., they favor the amputated side by placing more weight and increased ground reaction forces through the intact limb-w...
What is the current status of trial NCT04937179?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2022-07-01. Estimated completion is 2024-12-31.
What interventions are being tested in trial NCT04937179?
The interventions under investigation include: Ischemic Conditioning Low - Sham Comparator (PROCEDURE), Ischemic Conditioning High - Active Comparator (PROCEDURE).
Who is sponsoring clinical trial NCT04937179?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
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