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ACTIVE NOT RECRUITING Phase 3

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

NCT04822181 · View on ClinicalTrials.gov ↗

Study Summary

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to inject themselves with medicine under the skin. Participants will need to do this once a week. The study will last for about 5 years. Participants will have up to 21 clinic visits and 9 phone calls with the clinical staff during the study. Some of the clinic visits may be spread over more than one day. Participants with other chronic liver diseases cannot take part in this study. Women cannot take part in the study if they are pregnant, breast-feeding or plan to become pregnant during the study period.

Interventions

  • DRUG Placebo
  • DRUG Semaglutide

Study Locations (20)

California

  • Gastroenterology & Liver Institute — Escondido
  • Shang Wu M.D. Inc. — Hacienda Heights
  • Scripps Whittier Diabetes Inst — La Jolla
  • UCSD NAFLD Research Center — La Jolla
  • OM Research LLC — Lancaster
  • Digestive Hlth Res of SoCa — Long Beach
  • OM Research LLC — Oxnard
  • Cedars-Sinai Medical Center — Pasadena
  • Pasedena Liver Center — Pasadena
  • Inland Empire Clin Trials LLC — Rialto
  • UC Davis Hlth -Midtwn Ambu Cen — Sacramento
  • University of California, San Francisco — San Francisco

Arizona

  • The Institute for Liver Health — Chandler
  • Inst-Liver Hlth dba AZ Liver H — Peoria
  • Inst. Liver H II dba AZ Liver H — Tucson
  • Del Sol Research Management, LLC — Tucson

Arkansas

  • ARcare Center for Clinical Research — Jonesboro
  • ARcare Center for Clinical Research — Little Rock
  • Arkansas Diagnostic Center, PA — Little Rock

Alabama

  • North AL Health Res, LLC — Huntsville

Trial Details

FieldValue
Enrollment Target 1,205 participants
Start Date 2021-04-01
Est. Completion 2029-04-25
Phase Phase 3

Sponsor

Novo Nordisk A/S

189 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04822181

The ClinicalTrials.gov registry entry for NCT04822181 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,205 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novo Nordisk A/S, which has 189 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non-alcoholic Steatohepatitis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04822181 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Arizona, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04822181 about?

NCT04822181 is a clinical study titled "Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)". Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Particip...

What is the current status of trial NCT04822181?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,205 participants. The study started on 2021-04-01. Estimated completion is 2029-04-25.

What conditions does trial NCT04822181 study?

This clinical trial studies the following conditions: Non-alcoholic Steatohepatitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04822181?

The interventions under investigation include: Placebo (DRUG), Semaglutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04822181?

This trial is sponsored by Novo Nordisk A/S, which has 189 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04822181 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial