Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer
NCT04736173 · View on ClinicalTrials.gov ↗
Study Summary
This is a phase 2 study to evaluate zimberelimab (AB122) combined with domvanalimab (AB154) in front-line, PD-L1-high, locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC).
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Pemetrexed
- DRUG Paclitaxel
- DRUG Zimberelimab
- DRUG Domvanalimab
Study Locations (20)
Other
- Hong Kong United Oncology Centre — Hong Kong
- Humanity and Health Clinical Trial Centre — Hong Kong
- Hospital Sultan Ismail — Johor Bahru
- Hospital Kuala Lumpur — Kuala Lumpur
- Pantai Hospital Kuala Lumpur — Kuala Lumpur
- Universiti Kebangsaan Malaysia Medical Centre — Kuala Lumpur
- University Malaya Medical Centre — Kuala Lumpur
- Hospital Tengku Ampuan Afzan — Kuantan
- Hospital Umum Sarawak — Kuching
- Hospital Pulau Pinang — Pulau Pinang
- Institut Kanser Negara — Putrajaya
- Metro Davao Medical And Research Center Inc. — Davao City
- Philippine General Hospital — Manila
- St Luke's Medical Center — Manila
- Exellentis Clinical Trial Consultants — George
- Cancercare PE — Johannesburg
- University of Pretoria Medical Oncology — Pretoria
Georgia
- John B. Amos Cancer Center — Columbus
Texas
- Lumi Cancer Institute — Kingwood
Virginia
- Oncology and Hematology Associates of Southwest Virginia, Inc. — Blacksburg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 169 participants |
| Start Date | 2021-02-08 |
| Est. Completion | 2027-05 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04736173
The ClinicalTrials.gov registry entry for NCT04736173 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 169 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arcus Biosciences, which has 14 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04736173 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Other, Georgia, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04736173 about?
NCT04736173 is a clinical study titled "Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer". This is a phase 2 study to evaluate zimberelimab (AB122) combined with domvanalimab (AB154) in front-line, PD-L1-high, locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC).
What is the current status of trial NCT04736173?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 169 participants. The study started on 2021-02-08. Estimated completion is 2027-05.
What conditions does trial NCT04736173 study?
This clinical trial studies the following conditions: Lung Cancer, Non Small Cell Lung Cancer, Nonsquamous Non Small Cell Lung Cancer, Squamous Non Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04736173?
The interventions under investigation include: Carboplatin (DRUG), Pemetrexed (DRUG), Paclitaxel (DRUG), Zimberelimab (DRUG), Domvanalimab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04736173?
This trial is sponsored by Arcus Biosciences, which has 14 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04736173 being conducted?
This trial has 20 study locations across Georgia, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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