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NCT04578912 · ClinicalTrials.gov registry record · NA
Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics
A NA study of Tourette Syndrome and Tic Disorders, sponsored by University of Minnesota.
- Completed
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT04578912: Completed NA study of Tourette Syndrome and Tic Disorders, sponsored by University of Minnesota.
NCT04578912 is a NA study of Tourette Syndrome and Tic Disorders that has completed, run by University of Minnesota. The registered enrollment target is 50 participants, below the 85-participant average among 33 other Tourette Syndrome trials with a reported enrollment target (41% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04578912, a NA study of Tourette Syndrome and Tic Disorders, has completed, sponsored by University of Minnesota.
- COMPLETED
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The study will examine whether combining Comprehensive Behavioral Intervention for Tics (CBIT) with inhibition of the supplementary motor area (SMA) using transcranial magnetic stimulation (TMS) normalizes activity in the SMA-connected circuits, improves tic suppression ability, and enhances CBIT outcomes in young people with tic disorder. The study will also examine different TMS dosing strategies.
Primary Outcome
For each participant, signal intensity (unitless measure) will be measured using fMRI in the supplementary motor area (SMA) during a finger tapping task. An ANOVA will be conducted to compare change in signal intensity within SMA from pre- to post-treatment across the groups. The outcome will be reported as an effect size value (Cohen's d).
Conditions Studied
Interventions
- DEVICE Repetitive Transcranial Magnetic Stimulation (rTMS)
- BEHAVIORAL Comprehensive Behavioral Intervention for Tics (CBIT)
- DEVICE Continuous Theta Burst Stimulation (cTBS)
Study Locations (1)
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2020-11-01 |
| Est. Completion | 2023-12-31 |
| Phase | NA |
What the finished NCT04578912 record still lists
NCT04578912 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 85-participant average among 33 other Tourette Syndrome trials with a reported enrollment target (41% lower).
The record links to 7 conditions, with Tourette Syndrome appearing as the primary indexed condition, and to 3 interventions - of which Repetitive Transcranial Magnetic Stimulation (rTMS) is the first listed.
NCT04578912 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT04578912 about?
NCT04578912 is a clinical study titled "Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics". The study will examine whether combining Comprehensive Behavioral Intervention for Tics (CBIT) with inhibition of the supplementary motor area (SMA) using transcranial magnetic stimulation (TMS) normalizes activity in the SMA-connected circuits, improves tic suppression ability, and enhances CBIT ou...
What is the current status of trial NCT04578912?
This trial is currently completed. It is a NA study. The enrollment target is 50 participants. The study started on 2020-11-01. Estimated completion is 2023-12-31.
What conditions does trial NCT04578912 study?
This clinical trial studies the following conditions: Tourette Syndrome, Tic Disorders, Tourette Syndrome in Adolescence, Tics, Tourette Syndrome in Children.
What interventions are being tested in trial NCT04578912?
The interventions under investigation include: Repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE), Comprehensive Behavioral Intervention for Tics (CBIT) (BEHAVIORAL), Continuous Theta Burst Stimulation (cTBS) (DEVICE).
Who is sponsoring clinical trial NCT04578912?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04578912 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tourette Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04578912's enrollment target sits among peer trials
50 18th of 33 higher than 16 of 33 other Tourette Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tourette Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Remote Delivery of a Mindfulness-based Intervention for Tics
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Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study
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Tourette Deep Brain Stimulation (DBS) Target Detection & Suppression
ACTIVE NOT RECRUITING · NA
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Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals
ACTIVE NOT RECRUITING · NA
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