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NCT05705999 · ClinicalTrials.gov registry record · NA
Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study
A NA study of Tourette Syndrome, sponsored by West Virginia University.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT05705999: Recruiting NA study of Tourette Syndrome, sponsored by West Virginia University.
NCT05705999 is a NA study of Tourette Syndrome that is actively recruiting participants, run by West Virginia University. The registered enrollment target is 20 participants, below the 86-participant average among 33 other Tourette Syndrome trials with a reported enrollment target (77% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05705999, a NA study of Tourette Syndrome, is actively recruiting participants, sponsored by West Virginia University.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with Tourette's Syndrome (TS). Two groups of moderate disease severity will be randomized to receive active or sham rTMS targeted to the supplementary motor area (SMA) followed by eight CBIT sessions. The change in tic frequency and severity (primary outcome) and neurophysiological changes (secondary outcome) will be compared between the two groups. The central hypothesis is that low frequency rTMS will augment the effects of CBIT through favorable priming of the SMA network.
Primary Outcome
Tic severity will be measured with YGTSS. YGTSS is a clinician-rated scale used to assess tic severity, scored out of 100 where a higher score indicates greater tic frequency and severity. It includes a checklist of motor and vocal tics followed by an assessment of the number, frequency, intensity, complexity, and inference of motor tics and phonic tics - scored separately. Each of these dimensions is scored on a 0 to 5 scale. The YGTSS provides three tic severity scores: Total Motor (0 to 25);
Conditions Studied
Interventions
- DEVICE transcranial magnetic stimulation
Study Locations (1)
West Virginia
- WVU RNI - Morgantown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2024-03-12 |
| Est. Completion | 2026-12-30 |
| Phase | NA |
What NCT05705999 shows while recruiting
NCT05705999 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 86-participant average among 33 other Tourette Syndrome trials with a reported enrollment target (77% lower).
The record links to 1 condition, with Tourette Syndrome appearing as the primary indexed condition, and to 1 intervention - of which transcranial magnetic stimulation is the first listed.
NCT05705999 reports a single indexed study location in West Virginia.
Frequently Asked Questions
What is clinical trial NCT05705999 about?
NCT05705999 is a clinical study titled "Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study". This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with Tourette's Syndrome (TS). Two groups of moderate disease severity will be rand...
What is the current status of trial NCT05705999?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2024-03-12. Estimated completion is 2026-12-30.
What conditions does trial NCT05705999 study?
This clinical trial studies the following conditions: Tourette Syndrome.
What interventions are being tested in trial NCT05705999?
The interventions under investigation include: transcranial magnetic stimulation (DEVICE).
Who is sponsoring clinical trial NCT05705999?
This trial is sponsored by West Virginia University, which has 122 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05705999 being conducted?
This trial has 1 study location across West Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tourette Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05705999's enrollment target sits among peer trials
20 27th of 33 higher than 5 of 33 other Tourette Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tourette Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Tourette Deep Brain Stimulation (DBS) Target Detection & Suppression
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Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals
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-
Repetitive Transcranial Magnetic Stimulation to Reduce Tics
COMPLETED · NA
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