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NCT04496479 · ClinicalTrials.gov registry record · Phase 2

Allogenic Hepatocyte Transplantation Into Periduodenal Lymph Nodes

A Phase 2 study of End Stage Liver DIsease, sponsored by LyGenesis.

Recruiting
Registry status
Phase 2
Development phase
12
Enrollment target
2
Study locations

NCT04496479 is a Phase 2 study of End Stage Liver DIsease that is actively recruiting participants, run by LyGenesis. The registered enrollment target is 12 participants, below the 491-participant average among 16 other End Stage Liver DIsease trials with a reported enrollment target (98% lower). The trial reports 2 study locations across 2 states.

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The verdict

NCT04496479, a Phase 2 study of End Stage Liver DIsease, is actively recruiting participants, sponsored by LyGenesis.

RECRUITING
Registry status
Phase 2
Development phase
12 participants
Enrollment target
2
Study locations

Study Summary

This Phase 2a clinical trial is a dose escalation study of the safety, tolerability, and efficacy of hepatocyte transplantation into lymph nodes via endoscopic ultrasound among subjects with end-stage liver disease.

Conditions Studied

End Stage Liver DIsease

Interventions

  • BIOLOGICAL LYG-LIV0001

Study Locations (2)

Massachusetts

  • Tufts Medical Center - Boston

Texas

  • Houston Methodist Hospital - Houston

Trial Details

FieldValue
Enrollment Target 12 participants
Start Date 2022-03-11
Est. Completion 2027-12-30
Phase Phase 2

Sponsor

LyGenesis

1 total trials

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What the Registry Record Tells You About NCT04496479

The ClinicalTrials.gov registry entry for NCT04496479 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 491-participant average among 16 other End Stage Liver DIsease trials with a reported enrollment target (98% lower). The listed sponsor is LyGenesis, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with End Stage Liver DIsease appearing as the primary indexed condition, and to 1 intervention - of which LYG-LIV0001 is the first listed.

NCT04496479 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Massachusetts, Texas.

Frequently Asked Questions

What is clinical trial NCT04496479 about?

NCT04496479 is a clinical study titled "Allogenic Hepatocyte Transplantation Into Periduodenal Lymph Nodes". This Phase 2a clinical trial is a dose escalation study of the safety, tolerability, and efficacy of hepatocyte transplantation into lymph nodes via endoscopic ultrasound among subjects with end-stage liver disease.

What is the current status of trial NCT04496479?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 12 participants. The study started on 2022-03-11. Estimated completion is 2027-12-30.

What conditions does trial NCT04496479 study?

This clinical trial studies the following conditions: End Stage Liver DIsease.

What interventions are being tested in trial NCT04496479?

The interventions under investigation include: LYG-LIV0001 (BIOLOGICAL).

Who is sponsoring clinical trial NCT04496479?

This trial is sponsored by LyGenesis, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04496479 being conducted?

This trial has 2 study locations across Massachusetts, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.