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NCT04467931 · ClinicalTrials.gov registry record
ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
A clinical trial of Hypertension and COVID, sponsored by University of Utah.
- Completed
- Registry status
- 22,213
- Enrollment target
- 1
- Study location
NCT04467931 is a study of Hypertension and COVID that has completed, run by University of Utah. The registered enrollment target is 22,213 participants, above the 3,460-participant average among 470 other Hypertension trials with a reported enrollment target (542% higher). The trial reports 1 study location across 1 state.
The verdict
NCT04467931, a study of Hypertension and COVID, has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- 22,213 participants
- Enrollment target
- 1
- Study location
Study Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, enters type II pneumocytes using angiotensin-converting enzyme 2 (ACE2). It is unclear whether ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) increase, decrease, or have no significant effect on ACE2 expression or activity. Therefore, ACEI and ARB may be harmful, beneficial, or have no impact on Coronavirus Disease 2019 severity and mortality. The Specific Aims of this observational study are: (1) Among SARS-CoV-2-positive outpatients, compare all-cause hospitalization and mortality rates between: 1.1 Current users of a range of doses of ACEI/ARB- vs. non- ACEI/ARB-based regimens, and 1.2 Current users of a range of doses of ACEI- vs. ARB-based regimens, and (2) Among those hospitalized for COVID-19, compare all-cause mortality between: 2.1 Current users of a range of doses of ACEI/ARB- vs. non- ACEI/ARB-based regimens, and 2.2 Current users of a range of doses of ACEI- vs. ARB-based regimens.
Conditions Studied
Interventions
- DRUG ACEI/ARB
- DRUG Non-ACEI/ARB
- DRUG ACEI
- DRUG ARB
Study Locations (1)
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22,213 participants |
| Start Date | 2020-01-19 |
| Est. Completion | 2020-12-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04467931
The ClinicalTrials.gov registry entry for NCT04467931 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 22,213 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 3,460-participant average among 470 other Hypertension trials with a reported enrollment target (542% higher). The listed sponsor is University of Utah, which has 818 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Hypertension appearing as the primary indexed condition, and to 4 interventions - of which ACEI/ARB is the first listed.
NCT04467931 reports 1 study location spanning 1 distinct geographic area - top geographies include Utah.
Frequently Asked Questions
What is clinical trial NCT04467931 about?
NCT04467931 is a clinical study titled "ACEI or ARB and COVID-19 Severity and Mortality in US Veterans". Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, enters type II pneumocytes using angiotensin-converting enzyme 2 (ACE2). It is unclear whether ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) increase, decrease, or have no significant ...
What is the current status of trial NCT04467931?
This trial is currently completed. The enrollment target is 22,213 participants. The study started on 2020-01-19. Estimated completion is 2020-12-31.
What conditions does trial NCT04467931 study?
This clinical trial studies the following conditions: Hypertension, COVID.
What interventions are being tested in trial NCT04467931?
The interventions under investigation include: ACEI/ARB (DRUG), Non-ACEI/ARB (DRUG), ACEI (DRUG), ARB (DRUG).
Who is sponsoring clinical trial NCT04467931?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04467931 being conducted?
This trial has 1 study location across Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.