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ACTIVE NOT RECRUITING Phase 2

MARGetuximab Or Trastuzumab (MARGOT)

NCT04425018 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to determine how well participants with stage II-III HER2-positive breast cancer respond to pre-operative treatment using one of two different combinations of drugs. Drugs and Combinations used: * Paclitaxel, Pertzumab and Margetuximab (Margenza) * Paclitaxel, Pertzumab and Trastuzumab (Herceptin)

Interventions

  • DRUG Trastuzumab
  • DRUG Paclitaxel
  • DRUG Pertuzumab
  • DRUG Margetuximab

Study Locations (14)

Massachusetts

  • Beth Israel Deaconess Medical Center — Boston
  • Dana Farber Cancer Institute — Boston
  • Dana-Farber Brigham Cancer Center - Foxborough — Foxborough
  • Dana-Farber at Milford — Milford
  • Dana-Farber at South Shore Hospital — Weymouth

Pennsylvania

  • UPMC Hillman Cancer Center - Arnold Palmer at Mountain View — Greensburg
  • UPMC Hillman Cancer Center - Arnold Palmer at Norwin — Irwin
  • University of Pittsburgh Medical Center — Pittsburgh

District of Columbia

  • Georgetown University Medical Center — Washington D.C.
  • MedStar Washington Hospital Center — Washington D.C.

Texas

  • Baylor College of Medicine Medical Center — Houston
  • MD Anderson Cancer Center — Houston

New York

  • Montefiore Medical Center — The Bronx

Washington

  • University of Washington Fred Hutchinson Cancer Care — Seattle

Trial Details

FieldValue
Enrollment Target 174 participants
Start Date 2020-07-13
Est. Completion 2027-07-01
Phase Phase 2

Sponsor

Dana-Farber Cancer Institute

819 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04425018

The ClinicalTrials.gov registry entry for NCT04425018 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 174 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Dana-Farber Cancer Institute, which has 819 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Breast Cancer appearing as the primary indexed condition, and to 4 interventions — of which Trastuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04425018 reports 14 study locations spanning 6 distinct geographic areas — top geographies include Massachusetts, Pennsylvania, District of Columbia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04425018 about?

NCT04425018 is a clinical study titled "MARGetuximab Or Trastuzumab (MARGOT)". The purpose of this study is to determine how well participants with stage II-III HER2-positive breast cancer respond to pre-operative treatment using one of two different combinations of drugs. Drugs and Combinations used: * Paclitaxel, Pertzumab and Margetuximab (Margenza) * Paclitaxel, Pertzuma...

What is the current status of trial NCT04425018?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 174 participants. The study started on 2020-07-13. Estimated completion is 2027-07-01.

What conditions does trial NCT04425018 study?

This clinical trial studies the following conditions: Breast Cancer, HER2-positive Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04425018?

The interventions under investigation include: Trastuzumab (DRUG), Paclitaxel (DRUG), Pertuzumab (DRUG), Margetuximab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04425018?

This trial is sponsored by Dana-Farber Cancer Institute, which has 819 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04425018 being conducted?

This trial has 14 study locations across District of Columbia, Massachusetts, New York, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial