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NCT04334707 · ClinicalTrials.gov registry record

Kidney Precision Medicine Project

A clinical trial of Chronic Kidney Diseases and Acute Renal Failure, sponsored by University of Washington.

Recruiting
Registry status
1,000
Enrollment target
8
Study locations

NCT04334707 is a study of Chronic Kidney Diseases and Acute Renal Failure that is actively recruiting participants, run by University of Washington. The registered enrollment target is 1,000 participants, above the 431-participant average among 73 other Chronic Kidney Diseases trials with a reported enrollment target (132% higher). The trial reports 8 study locations across 7 states.

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The verdict

NCT04334707, a study of Chronic Kidney Diseases and Acute Renal Failure, is actively recruiting participants, sponsored by University of Washington.

RECRUITING
Registry status
1,000 participants
Enrollment target
8
Study locations

Study Summary

Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Despite significant effort from industry and academia, development of pharmacologic therapies for AKI and CKD has been hampered by: Non-predictive animal models The inability to identify and prioritize human targets The limited availability of human kidney biopsy tissue A poor understanding of AKI and CKD heterogeneity Historically, AKI and CKD have been described as single, uniform diseases. However, growing consensus suggests that different disease pathways lead to different subgroups of AKI and CKD (AKIs and CKDs). Access to human kidney biopsy tissue is a critical first step to define disease heterogeneity and determine the precise molecular pathways that will facilitate identification of specific drug targets and ultimately enable individualized care for people with AKI and CKD. A number of research centers across the United States are collaborating to bring state-of-the-art technologies together to: * Ethically obtain and evaluate kidney biopsies from participants with AKI or CKD * Define disease subgroups * Create a kidney tissue atlas * Identify critical cells, pathways, and targets for novel therapies The KPMP is made up of three distinct, but highly interactive, activity groups: * Recruitment Sites: The recruitment sites (RS) are responsible for recruiting participants with AKI or CKD into the longitudinal study and performing the kidney biopsy. * Tissue Interrogation Sites: The tissue interrogation sites (TIS) are responsible for developing and using innovative technologies to analyze the biopsy tissue. * Central Hub: The central hub is responsible for aggregating, analyzing, and visualizing the generated data and providing scientific, infrastructure, and administrative support for the KPMP consortium.

Conditions Studied

Chronic Kidney Diseases Acute Renal Failure Acute Kidney Failure Renal Failure, Acute Acute Kidney Insufficiency Acute Renal Injury Acute Renal Insufficiency Kidney Failure, Acute Kidney Insufficiency, Acute Renal Insufficiency, Acute

Interventions

  • PROCEDURE Kidney Biopsy

Study Locations (8)

Massachusetts

  • Brigham & Women's Hospital - Boston
  • Joslin Diabetes Center - Boston

Connecticut

  • Yale University - New Haven

Maryland

  • Johns Hopkins University - Baltimore

New York

  • Columbia University - New York

Ohio

  • Cleveland Clinic - Cleveland

Pennsylvania

  • University of Pittsburgh - Pittsburgh

Texas

  • University of Texas at Southwestern - Dallas

Trial Details

FieldValue
Enrollment Target 1,000 participants
Start Date 2019-09-01
Est. Completion 2027-06-30

Sponsor

University of Washington

1,048 total trials

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What the Registry Record Tells You About NCT04334707

The ClinicalTrials.gov registry entry for NCT04334707 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 1,000 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 431-participant average among 73 other Chronic Kidney Diseases trials with a reported enrollment target (132% higher). The listed sponsor is University of Washington, which has 1,048 total studies on file at ClinicalTrials.gov.

The record links to 10 conditions, with Chronic Kidney Diseases appearing as the primary indexed condition, and to 1 intervention - of which Kidney Biopsy is the first listed.

NCT04334707 reports 8 study locations spanning 7 distinct geographic areas - top geographies include Massachusetts, Connecticut, Maryland.

Frequently Asked Questions

What is clinical trial NCT04334707 about?

NCT04334707 is a clinical study titled "Kidney Precision Medicine Project". Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Despite significant effort from industry and academia, development of pharmacologic therapies for AKI and ...

What is the current status of trial NCT04334707?

This trial is currently recruiting. The enrollment target is 1,000 participants. The study started on 2019-09-01. Estimated completion is 2027-06-30.

What conditions does trial NCT04334707 study?

This clinical trial studies the following conditions: Chronic Kidney Diseases, Acute Renal Failure, Acute Kidney Failure, Renal Failure, Acute, Acute Kidney Insufficiency.

What interventions are being tested in trial NCT04334707?

The interventions under investigation include: Kidney Biopsy (PROCEDURE).

Who is sponsoring clinical trial NCT04334707?

This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04334707 being conducted?

This trial has 8 study locations across Connecticut, Maryland, Massachusetts, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.