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NCT04328337 · ClinicalTrials.gov registry record · Phase 1
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
A Phase 1 study of Obesity, sponsored by University of North Carolina, Chapel Hill.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 2
- Study locations
NCT04328337: Recruiting Phase 1 study of Obesity, sponsored by University of North Carolina, Chapel Hill.
NCT04328337 is a Phase 1 study of Obesity that is actively recruiting participants, run by University of North Carolina, Chapel Hill. The registered enrollment target is 40 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (95% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04328337, a Phase 1 study of Obesity, is actively recruiting participants, sponsored by University of North Carolina, Chapel Hill.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are that this reduction is driven by elevated non esterified fatty acids which act to turn on specific signaling pathways that regulate brain GLUT1 levels.
Primary Outcome
Measurement of brain glucose transport rates using magnetic resonance spectroscopy (MRS).
Conditions Studied
Interventions
- DRUG Placebos
- DRUG Intralipid, 20% Intravenous Emulsion
Study Locations (2)
North Carolina
- Biomedical Research Imaging Center Marsico Hall (UNC) - Chapel Hill
- Clinical and Translational Research Center (CTRC) Burnett-Womack Building (UNC) - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2020-12-08 |
| Est. Completion | 2026-06-01 |
| Phase | Phase 1 |
What NCT04328337 shows while recruiting
NCT04328337 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Placebos is the first listed.
NCT04328337 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT04328337 about?
NCT04328337 is a clinical study titled "Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism". The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we...
What is the current status of trial NCT04328337?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2020-12-08. Estimated completion is 2026-06-01.
What conditions does trial NCT04328337 study?
This clinical trial studies the following conditions: Obesity.
What interventions are being tested in trial NCT04328337?
The interventions under investigation include: Placebos (DRUG), Intralipid, 20% Intravenous Emulsion (DRUG).
Who is sponsoring clinical trial NCT04328337?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04328337 being conducted?
This trial has 2 study locations across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04328337's enrollment target sits among peer trials
40 778th of 1053 higher than 249 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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