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NCT04309370 · ClinicalTrials.gov registry record · NA

Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia

A NA study of Schizophrenia, sponsored by Indiana University.

Completed
Registry status
NA
Development phase
14
Enrollment target
2
Study locations

NCT04309370 is a NA study of Schizophrenia that has completed, run by Indiana University. The registered enrollment target is 14 participants, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (94% lower). The trial reports 2 study locations across 1 state.

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The verdict

NCT04309370, a NA study of Schizophrenia, has completed, sponsored by Indiana University.

COMPLETED
Registry status
NA
Development phase
14 participants
Enrollment target
2
Study locations

Study Summary

This will be a single site pilot study. 20 subjects with EPP (Early Phase Psychosis), defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past 10 years, will be enrolled. Prior to randomization subjects will undergo fMRI (Functional Magnetic Resonance Imaging) during CC (Cognitive Control) task (Stroop Color-Word paradigm) and resting-state paradigms. This baseline scan will also include a high-resolution structural sequence for neuronavigation purposes. Then, on two separate days, each occurring one-week apart, subjects will receive one session of excitatory (20 Hz) (Hertz) rTMS (Repetitive Transcranial Magnetic Stimulation) targeting the LDLPFC (Left Dorsolateral Prefrontal Cortex) and one session targeting the LSPC (Left Superior Parietal Cortex). The order of stimulation sites will be randomized and counter-balanced. Immediately following each session, subjects will undergo repeat fMRI during CC and RS (Resting State) paradigms. Investigators will also examine the effect of rTMS on CC performance.

Conditions Studied

Schizophrenia

Interventions

  • DEVICE 20 Hz rTMS

Study Locations (2)

Indiana

  • IU Center for Neuroimaging - Indianapolis
  • Prevention and Recovery Center for Early Psychosis - Indianapolis

Trial Details

FieldValue
Enrollment Target 14 participants
Start Date 2020-03-12
Est. Completion 2022-04-15
Phase NA

Sponsor

Indiana University

890 total trials

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What the Registry Record Tells You About NCT04309370

The ClinicalTrials.gov registry entry for NCT04309370 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (94% lower). The listed sponsor is Indiana University, which has 890 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Schizophrenia appearing as the primary indexed condition, and to 1 intervention - of which 20 Hz rTMS is the first listed.

NCT04309370 reports 2 study locations spanning 1 distinct geographic area - top geographies include Indiana.

Frequently Asked Questions

What is clinical trial NCT04309370 about?

NCT04309370 is a clinical study titled "Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia". This will be a single site pilot study. 20 subjects with EPP (Early Phase Psychosis), defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past 10 years, will be enrolled. Prior to randomization subjects will undergo fMRI (Functional Magnetic R...

What is the current status of trial NCT04309370?

This trial is currently completed. It is a NA study. The enrollment target is 14 participants. The study started on 2020-03-12. Estimated completion is 2022-04-15.

What conditions does trial NCT04309370 study?

This clinical trial studies the following conditions: Schizophrenia.

What interventions are being tested in trial NCT04309370?

The interventions under investigation include: 20 Hz rTMS (DEVICE).

Who is sponsoring clinical trial NCT04309370?

This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04309370 being conducted?

This trial has 2 study locations across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.