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NCT04156893 · ClinicalTrials.gov registry record · Phase 1
RH Genotype Matched RBC Transfusions
A Phase 1 study of Sickle Cells Disease, sponsored by Children's Hospital of Philadelphia.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 35
- Enrollment target
- 1
- Study location
NCT04156893: Recruiting Phase 1 study of Sickle Cells Disease, sponsored by Children's Hospital of Philadelphia.
NCT04156893 is a Phase 1 study of Sickle Cells Disease that is actively recruiting participants, run by Children's Hospital of Philadelphia. The registered enrollment target is 35 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04156893, a Phase 1 study of Sickle Cells Disease, is actively recruiting participants, sponsored by Children's Hospital of Philadelphia.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 35 participants
- Enrollment target
- 1
- Study location
Study Summary
To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
Primary Outcome
A primary objective is to determine whether providing RH genotype matched red cell units can reduce or prevent Rh alloimmunization.
Conditions Studied
Interventions
- BIOLOGICAL Red cell units that are genotype matched at the RHD and RHCE loci
Study Locations (1)
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2020-01-30 |
| Est. Completion | 2029-10 |
| Phase | Phase 1 |
What NCT04156893 shows while recruiting
NCT04156893 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% lower).
The record links to 1 condition, with Sickle Cells Disease appearing as the primary indexed condition, and to 1 intervention - of which Red cell units that are genotype matched at the RHD and RHCE loci is the first listed.
NCT04156893 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04156893 about?
NCT04156893 is a clinical study titled "RH Genotype Matched RBC Transfusions". To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
What is the current status of trial NCT04156893?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 35 participants. The study started on 2020-01-30. Estimated completion is 2029-10.
What conditions does trial NCT04156893 study?
This clinical trial studies the following conditions: Sickle Cells Disease.
What interventions are being tested in trial NCT04156893?
The interventions under investigation include: Red cell units that are genotype matched at the RHD and RHCE loci (BIOLOGICAL).
Who is sponsoring clinical trial NCT04156893?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04156893 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04156893's enrollment target sits among peer trials
35 1259th of 2000 higher than 728 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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