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NCT04134325 · ClinicalTrials.gov registry record · Early Phase 1
Study of PD-1 Inhibitors After CD30.CAR T Cell Therapy in Relapsed/Refractory Hodgkin Lymphoma
A Early Phase 1 study of Refractory Hodgkin Lymphoma and Relapsed Hodgkin Lymphoma, sponsored by UNC Lineberger Comprehensive Cancer Center.
- Active
- Registry status
- Early Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT04134325: Active Early Phase 1 study of Refractory Hodgkin Lymphoma and Relapsed Hodgkin Lymphoma, sponsored by UNC Lineberger Comprehensive Cancer Center.
NCT04134325 is a Early Phase 1 study of Refractory Hodgkin Lymphoma and Relapsed Hodgkin Lymphoma that is active but no longer recruiting, run by UNC Lineberger Comprehensive Cancer Center. The registered enrollment target is 10 participants, below the 41-participant average among 11 other Refractory Hodgkin Lymphoma trials with a reported enrollment target (76% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04134325, a Early Phase 1 study of Refractory Hodgkin Lymphoma and Relapsed Hodgkin Lymphoma, is active but no longer recruiting, sponsored by UNC Lineberger Comprehensive Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
LCCC1852-ATL is a prospective 2-arm study designed to determine if chimeric antigen receptor T (CAR-T) cells result in immunomodulation which can be subsequently exploited by programmed cell death protein 1 (PD-1) antibodies to achieve clinical responses in subjects with relapsed/refractory (r/r) classical Hodgkin Lymphoma (cHL).
Primary Outcome
Response will be determined by the Lymphoma Response to Immunomodulatory Therapy Criteria in order to evaluate the efficacy of anti-PD-1 therapy after progression on CD30 CAR-T cell therapy in relapsed/refractory (r/r) classical Hodgkin Lymphoma (cHL).
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
- BIOLOGICAL Nivolumab
Study Locations (1)
North Carolina
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2019-09-01 |
| Est. Completion | 2037-07-07 |
| Phase | Early Phase 1 |
What the registry record for NCT04134325 still lists
NCT04134325 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 41-participant average among 11 other Refractory Hodgkin Lymphoma trials with a reported enrollment target (76% lower).
The record links to 2 conditions, with Refractory Hodgkin Lymphoma appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT04134325 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT04134325 about?
NCT04134325 is a clinical study titled "Study of PD-1 Inhibitors After CD30.CAR T Cell Therapy in Relapsed/Refractory Hodgkin Lymphoma". LCCC1852-ATL is a prospective 2-arm study designed to determine if chimeric antigen receptor T (CAR-T) cells result in immunomodulation which can be subsequently exploited by programmed cell death protein 1 (PD-1) antibodies to achieve clinical responses in subjects with relapsed/refractory (r/r) cl...
What is the current status of trial NCT04134325?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 10 participants. The study started on 2019-09-01. Estimated completion is 2037-07-07.
What conditions does trial NCT04134325 study?
This clinical trial studies the following conditions: Refractory Hodgkin Lymphoma, Relapsed Hodgkin Lymphoma.
What interventions are being tested in trial NCT04134325?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Nivolumab (BIOLOGICAL).
Who is sponsoring clinical trial NCT04134325?
This trial is sponsored by UNC Lineberger Comprehensive Cancer Center, which has 366 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04134325 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04134325's enrollment target sits among peer trials
10 12th of 11 the lowest of 11 other Refractory Hodgkin Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Refractory Hodgkin Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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