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NCT04058431 · ClinicalTrials.gov registry record · NA

Osteopathic Manipulation Makes a Neuropsychological Difference

A NA study of Cognitive Change and Musculoskeletal Pain, sponsored by Midwestern University.

Active
Registry status
NA
Development phase
100
Enrollment target
1
Study location

NCT04058431: Active NA study of Cognitive Change and Musculoskeletal Pain, sponsored by Midwestern University.

NCT04058431 is a NA study of Cognitive Change and Musculoskeletal Pain that is active but no longer recruiting, run by Midwestern University. The registered enrollment target is 100 participants, below the 178-participant average among 44 other Cognitive Change trials with a reported enrollment target (44% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04058431, a NA study of Cognitive Change and Musculoskeletal Pain, is active but no longer recruiting, sponsored by Midwestern University.

ACTIVE NOT RECRUITING
Registry status
NA
Development phase
100 participants
Enrollment target
1
Study location

Study Summary

Patients with pain commonly experience cognitive impairment. While symptoms of pain are effectively treated with osteopathic manipulative treatment (OMT), the cognitive piece is vastly ignored. Pain-induced cognitive dysfunction can be severe and is particularly apparent in working memory and attention. There is good reason to also expect cognitive responsiveness to OMT. Previous research has already reported related psychiatric outcomes, including relief from stress, self-perception and anxiety, suggesting that OMT may produce more global effects on cortical processing than currently thought.

Primary Outcome

standardized assessment battery

Interventions

  • OTHER Osteopathic Manipulative Treatment
  • OTHER Control- No Intervention

Study Locations (1)

Illinois

  • Midwestern Multispecialty Clinic - Downers Grove

Trial Details

FieldValue
Enrollment Target 100 participants
Start Date 2017-01
Est. Completion 2026-09
Phase NA
Midwestern University

15 total trials

What the registry record for NCT04058431 still lists

NCT04058431 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 178-participant average among 44 other Cognitive Change trials with a reported enrollment target (44% lower).

The record links to 2 conditions, with Cognitive Change appearing as the primary indexed condition, and to 2 interventions - of which Osteopathic Manipulative Treatment is the first listed.

NCT04058431 reports a single indexed study location in Illinois.

Frequently Asked Questions

What is clinical trial NCT04058431 about?

NCT04058431 is a clinical study titled "Osteopathic Manipulation Makes a Neuropsychological Difference". Patients with pain commonly experience cognitive impairment. While symptoms of pain are effectively treated with osteopathic manipulative treatment (OMT), the cognitive piece is vastly ignored. Pain-induced cognitive dysfunction can be severe and is particularly apparent in working memory and attent...

What is the current status of trial NCT04058431?

This trial is currently active not recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2017-01. Estimated completion is 2026-09.

What conditions does trial NCT04058431 study?

This clinical trial studies the following conditions: Cognitive Change, Musculoskeletal Pain.

What interventions are being tested in trial NCT04058431?

The interventions under investigation include: Osteopathic Manipulative Treatment (OTHER), Control- No Intervention (OTHER).

Who is sponsoring clinical trial NCT04058431?

This trial is sponsored by Midwestern University, which has 15 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04058431 being conducted?

This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Similar trials for Cognitive Change

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04058431's enrollment target sits among peer trials

100 14th of 44 higher than 30 of 44 other Cognitive Change trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Cognitive Change trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT04058431, the US trial registry maintained by the National Library of Medicine. NCT04058431 (mid enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.