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NCT06172621 · ClinicalTrials.gov registry record · NA
Spinal Cord Associative Plasticity for ALS
A NA study of Amyotrophic Lateral Sclerosis, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- NA
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT06172621: Recruiting NA study of Amyotrophic Lateral Sclerosis, sponsored by VA Office of Research and Development.
NCT06172621 is a NA study of Amyotrophic Lateral Sclerosis that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 32 participants, below the 898-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06172621, a NA study of Amyotrophic Lateral Sclerosis, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- NA
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
Veterans are at higher risk than non-Veterans of falling ill with amyotrophic lateral sclerosis (ALS). The investigators have shown that synchronized stimulation over the brain and cervical spinal cord can temporarily strengthen weakened nerve circuits between the brain and hand muscles in people with ALS. The current proposal will take the next step of individualizing this intervention, then applying it repetitively in an attempt to achieve direct clinical benefit on hand strength and function. Following an initial 2-3 month period of optimizing the intervention for each individual, the investigators will compare the effects of two-week programs of paired brain-spinal stimulation with or without hand exercises.
Primary Outcome
The primary neurophysiological outcome will be corticospinal excitability measured at the first dorsal interosseous (FDI) muscle. If no suitable FDI muscle, will substitute with abductor pollicis brevis (APB) muscle.
Conditions Studied
Interventions
- PROCEDURE Spinal Cord Associative Plasticity (SCAP)
- PROCEDURE Upper extremity task-oriented exercise
Study Locations (1)
New York
- James J. Peters VA Medical Center, Bronx, NY - The Bronx
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2024-04-01 |
| Est. Completion | 2028-02-29 |
| Phase | NA |
What NCT06172621 shows while recruiting
NCT06172621 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 898-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Amyotrophic Lateral Sclerosis appearing as the primary indexed condition, and to 2 interventions - of which Spinal Cord Associative Plasticity (SCAP) is the first listed.
NCT06172621 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06172621 about?
NCT06172621 is a clinical study titled "Spinal Cord Associative Plasticity for ALS". Veterans are at higher risk than non-Veterans of falling ill with amyotrophic lateral sclerosis (ALS). The investigators have shown that synchronized stimulation over the brain and cervical spinal cord can temporarily strengthen weakened nerve circuits between the brain and hand muscles in people w...
What is the current status of trial NCT06172621?
This trial is currently recruiting. It is a NA study. The enrollment target is 32 participants. The study started on 2024-04-01. Estimated completion is 2028-02-29.
What conditions does trial NCT06172621 study?
This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis.
What interventions are being tested in trial NCT06172621?
The interventions under investigation include: Spinal Cord Associative Plasticity (SCAP) (PROCEDURE), Upper extremity task-oriented exercise (PROCEDURE).
Who is sponsoring clinical trial NCT06172621?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06172621 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Amyotrophic Lateral Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06172621's enrollment target sits among peer trials
32 63rd of 102 higher than 40 of 102 other Amyotrophic Lateral Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Amyotrophic Lateral Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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