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NCT03705793 · ClinicalTrials.gov registry record · Phase 4
Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis
A Phase 4 study of Chronic Rhinosinusitis (Diagnosis) and Allergic Rhinosinusitis, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Phase 4
- Development phase
- 53
- Enrollment target
- 2
- Study locations
NCT03705793: Completed Phase 4 study of Chronic Rhinosinusitis (Diagnosis) and Allergic Rhinosinusitis, sponsored by Washington University School of Medicine.
NCT03705793 is a Phase 4 study of Chronic Rhinosinusitis (Diagnosis) and Allergic Rhinosinusitis that has completed, run by Washington University School of Medicine. The registered enrollment target is 53 participants, below the 85-participant average among 9 other Chronic Rhinosinusitis (Diagnosis) trials with a reported enrollment target (38% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03705793, a Phase 4 study of Chronic Rhinosinusitis (Diagnosis) and Allergic Rhinosinusitis, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 53 participants
- Enrollment target
- 2
- Study locations
Study Summary
Chronic rhinosinusitis (CRS) affects up to 12.5% of the US population and has a significant disease burden. The recommended medical management of CRS includes large-volume, low-pressure saline lavage, systemic antibiotics, and intranasal corticosteroids (INCS). While the efficacy and safety of INCS are well-established for the long-term management of CRS, penetration of INCS beyond the nasal vestibule and into the paranasal sinuses is limited. The aim of this study is to evaluate the effectiveness of mometasone furoate large-volume, low-pressure nasal irrigation for surgery-naive CRS patients.
Primary Outcome
The change in Sino-Nasal Outcome Test scores (SNOT-22) scores pre- and post-treatment between the two arms was measured. The Sino-Nasal Outcome Test asks subjects to rate how "bad" their rhinosinusitis is by using a 0-5 point scale with 0=no problem, 1=very mild problem, 2=mild or slight problem, 3=moderate problem, 4=severe problem, 5=problem as bad as it can be. The SNOT includes 22 questions (symptoms and social/emotional consequences of rhinosinusitis), each of which are rated from 0 to 5 fo
Conditions Studied
Interventions
- DRUG Mometasone Furoate Nasal Irrigation
- DRUG Mometasone Nasal Spray
Study Locations (2)
Missouri
- Washington University School of Medicine - St Louis
- Washington University - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 53 participants |
| Start Date | 2019-01-01 |
| Est. Completion | 2020-03-15 |
| Phase | Phase 4 |
What the finished NCT03705793 record still lists
NCT03705793 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 53 participants, a relatively small participant target, below the 85-participant average among 9 other Chronic Rhinosinusitis (Diagnosis) trials with a reported enrollment target (38% lower).
The record links to 3 conditions, with Chronic Rhinosinusitis (Diagnosis) appearing as the primary indexed condition, and to 2 interventions - of which Mometasone Furoate Nasal Irrigation is the first listed.
NCT03705793 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT03705793 about?
NCT03705793 is a clinical study titled "Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis". Chronic rhinosinusitis (CRS) affects up to 12.5% of the US population and has a significant disease burden. The recommended medical management of CRS includes large-volume, low-pressure saline lavage, systemic antibiotics, and intranasal corticosteroids (INCS). While the efficacy and safety of INCS ...
What is the current status of trial NCT03705793?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 53 participants. The study started on 2019-01-01. Estimated completion is 2020-03-15.
What conditions does trial NCT03705793 study?
This clinical trial studies the following conditions: Chronic Rhinosinusitis (Diagnosis), Allergic Rhinosinusitis, Chronic Eosinophilic Rhinosinusitis.
What interventions are being tested in trial NCT03705793?
The interventions under investigation include: Mometasone Furoate Nasal Irrigation (DRUG), Mometasone Nasal Spray (DRUG).
Who is sponsoring clinical trial NCT03705793?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03705793 being conducted?
This trial has 2 study locations across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Rhinosinusitis (Diagnosis)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03705793's enrollment target sits among peer trials
53 6th of 9 higher than 4 of 9 other Chronic Rhinosinusitis (Diagnosis) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Rhinosinusitis (Diagnosis) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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