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NCT05427695 · ClinicalTrials.gov registry record · Phase 2
Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis
A Phase 2 study of Chronic Rhinosinusitis (Diagnosis), sponsored by University of Illinois at Chicago.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT05427695: Recruiting Phase 2 study of Chronic Rhinosinusitis (Diagnosis), sponsored by University of Illinois at Chicago.
NCT05427695 is a Phase 2 study of Chronic Rhinosinusitis (Diagnosis) that is actively recruiting participants, run by University of Illinois at Chicago. The registered enrollment target is 60 participants, below the 84-participant average among 9 other Chronic Rhinosinusitis (Diagnosis) trials with a reported enrollment target (29% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05427695, a Phase 2 study of Chronic Rhinosinusitis (Diagnosis), is actively recruiting participants, sponsored by University of Illinois at Chicago.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this randomized study will be to determine whether topical probiotic sinus irrigations are more effective compared to saline sinus irrigation controls in the treatment of active CRS in patients who have had prior sinus surgery based on subjective and objective outcome measures.
Primary Outcome
It is expected that topical probiotic irrigations will result in a clinically significant change in symptom severity score (SNOT-22) (a change of 9 on a scale 0-110) compared to saline irrigations (primary outcome).
Conditions Studied
Interventions
- DRUG Lactobacillus sakei proBio65
- OTHER Isotonic Saline Solution
Study Locations (1)
Illinois
- University of Illinois Hospitals & Health Sciences System - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-02-05 |
| Est. Completion | 2026-07-30 |
| Phase | Phase 2 |
What NCT05427695 shows while recruiting
NCT05427695 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 84-participant average among 9 other Chronic Rhinosinusitis (Diagnosis) trials with a reported enrollment target (29% lower).
The record links to 1 condition, with Chronic Rhinosinusitis (Diagnosis) appearing as the primary indexed condition, and to 2 interventions - of which Lactobacillus sakei proBio65 is the first listed.
NCT05427695 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT05427695 about?
NCT05427695 is a clinical study titled "Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis". The purpose of this randomized study will be to determine whether topical probiotic sinus irrigations are more effective compared to saline sinus irrigation controls in the treatment of active CRS in patients who have had prior sinus surgery based on subjective and objective outcome measures.
What is the current status of trial NCT05427695?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2025-02-05. Estimated completion is 2026-07-30.
What conditions does trial NCT05427695 study?
This clinical trial studies the following conditions: Chronic Rhinosinusitis (Diagnosis).
What interventions are being tested in trial NCT05427695?
The interventions under investigation include: Lactobacillus sakei proBio65 (DRUG), Isotonic Saline Solution (OTHER).
Who is sponsoring clinical trial NCT05427695?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05427695 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Rhinosinusitis (Diagnosis)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05427695's enrollment target sits among peer trials
60 5th of 9 higher than 5 of 9 other Chronic Rhinosinusitis (Diagnosis) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Rhinosinusitis (Diagnosis) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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