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NCT06822725 · ClinicalTrials.gov registry record
The Sinonasal Microbiome
A clinical trial of Chronic Rhinosinusitis (Diagnosis) and Sinonasal Disorder, sponsored by University of Chicago.
- Active
- Registry status
- 285
- Enrollment target
- 1
- Study location
NCT06822725: Active study of Chronic Rhinosinusitis (Diagnosis) and Sinonasal Disorder, sponsored by University of Chicago.
NCT06822725 is a study of Chronic Rhinosinusitis (Diagnosis) and Sinonasal Disorder that is active but no longer recruiting, run by University of Chicago. The registered enrollment target is 285 participants, above the 59-participant average among 9 other Chronic Rhinosinusitis (Diagnosis) trials with a reported enrollment target (383% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06822725, a study of Chronic Rhinosinusitis (Diagnosis) and Sinonasal Disorder, is active but no longer recruiting, sponsored by University of Chicago.
- ACTIVE NOT RECRUITING
- Registry status
- 285 participants
- Enrollment target
- 1
- Study location
Study Summary
Chronic rhinosinusitis is an inflammatory disease of the sinonasal mucosa with significant impact and limited treatment options. Chronic rhinosinusitis (CRS) poses an important public health problem and causes a large impact on individual quality of life. Studies of CRS have been limited by access to tissue, the complexity of the sinonasal physiology, a lack of available biomarkers, the absence of useful animal models, a paucity of cohorts with biological samples for analysis, and limited well-designed clinical trials or investigations of immune function. Therefore, novel strategies for identifying biological mechanisms underlying this disease are in great need. Using prospective samples from well characterized subjects, the investigators intend to profile the mucosa associated-bacteria in the nose and sinuses. In parallel, using sinus tissue from patients undergoing surgery, the site will interrogate the epithelium for mucosal immune function to understand host-microbe interaction. This study hypothesizes that the microbial profile of the sinuses initiates an immune responses which leads to chronic inflammation in susceptible people. This study would provide the first comprehensive data on what bacteria are present in the nose and sinus and could lead to important knowledge useful in sinonasal disease.
Conditions Studied
Interventions
- OTHER Control Group
- PROCEDURE Chronic rhinosinusitis (CRS) with and without Nasal Polyposis
Study Locations (1)
Illinois
- The University of Chicago - Hyde Park
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 285 participants |
| Start Date | 2025-01-13 |
| Est. Completion | 2029-01 |
What the registry record for NCT06822725 still lists
NCT06822725 is an observational study that tracks outcomes without assigning an intervention. The registered 285 participants enrollment target is mid-sized for trials with a published cap, above the 59-participant average among 9 other Chronic Rhinosinusitis (Diagnosis) trials with a reported enrollment target (383% higher).
The record links to 2 conditions, with Chronic Rhinosinusitis (Diagnosis) appearing as the primary indexed condition, and to 2 interventions - of which Control Group is the first listed.
NCT06822725 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06822725 about?
NCT06822725 is a clinical study titled "The Sinonasal Microbiome". Chronic rhinosinusitis is an inflammatory disease of the sinonasal mucosa with significant impact and limited treatment options. Chronic rhinosinusitis (CRS) poses an important public health problem and causes a large impact on individual quality of life. Studies of CRS have been limited by access t...
What is the current status of trial NCT06822725?
This trial is currently active not recruiting. The enrollment target is 285 participants. The study started on 2025-01-13. Estimated completion is 2029-01.
What conditions does trial NCT06822725 study?
This clinical trial studies the following conditions: Chronic Rhinosinusitis (Diagnosis), Sinonasal Disorder.
What interventions are being tested in trial NCT06822725?
The interventions under investigation include: Control Group (OTHER), Chronic rhinosinusitis (CRS) with and without Nasal Polyposis (PROCEDURE).
Who is sponsoring clinical trial NCT06822725?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06822725 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Rhinosinusitis (Diagnosis)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06822725's enrollment target sits among peer trials
285 1st of 9 higher than 9 of 9 other Chronic Rhinosinusitis (Diagnosis) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Rhinosinusitis (Diagnosis) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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