Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03659513 · ClinicalTrials.gov registry record
The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
A clinical trial of Hypoxia and Extracorporeal Membrane Oxygenation Complication, sponsored by University of Pennsylvania.
- Completed
- Registry status
- 75
- Enrollment target
- 1
- Study location
NCT03659513: Completed study of Hypoxia and Extracorporeal Membrane Oxygenation Complication, sponsored by University of Pennsylvania.
NCT03659513 is a study of Hypoxia and Extracorporeal Membrane Oxygenation Complication that has completed, run by University of Pennsylvania. The registered enrollment target is 75 participants, below the 3,115-participant average among 39 other Hypoxia trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03659513, a study of Hypoxia and Extracorporeal Membrane Oxygenation Complication, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will examine the pharmacokinetics of the various, routinely given antibiotics, sedatives, and opioids in patients undergoing venous-venous extra-corporal oxygenation (ECMO). Little is known about the distribution and effectiveness of antibiotics in this particular patient population.
Primary Outcome
The primary outcome is the data describing the Maximal Serum Antibiotic Concentration (Cmax) of the antibiotics after the onset of infusion.This will be achieved by serial measurements of the serum antibiotic levels at discrete time points for total of 24 hours after starting antibiotics. We will calculate Cmax to demonstrate maximal concentration of the antibiotics.
Conditions Studied
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2016-09-13 |
| Est. Completion | 2022-10-24 |
What the finished NCT03659513 record still lists
NCT03659513 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 3,115-participant average among 39 other Hypoxia trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Hypoxia appearing as the primary indexed condition, and to 0 interventions.
NCT03659513 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT03659513 about?
NCT03659513 is a clinical study titled "The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy". This study will examine the pharmacokinetics of the various, routinely given antibiotics, sedatives, and opioids in patients undergoing venous-venous extra-corporal oxygenation (ECMO). Little is known about the distribution and effectiveness of antibiotics in this particular patient population.
What is the current status of trial NCT03659513?
This trial is currently completed. The enrollment target is 75 participants. The study started on 2016-09-13. Estimated completion is 2022-10-24.
What conditions does trial NCT03659513 study?
This clinical trial studies the following conditions: Hypoxia, Extracorporeal Membrane Oxygenation Complication.
Who is sponsoring clinical trial NCT03659513?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03659513 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypoxia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03659513's enrollment target sits among peer trials
75 14th of 39 higher than 25 of 39 other Hypoxia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypoxia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
RECRUITING · NA
-
Intravenous Iron Effects on Performance at High Altitude
RECRUITING · Phase 4
-
End-Tidal Oxygen for Intubation in the Emergency Department
RECRUITING · NA
-
Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
RECRUITING · Phase 2
-
Pulse Oximeter Accuracy in Healthy Humans During Hypoxia
RECRUITING
-
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
RECRUITING · Early Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01535430 · 75 participants
Assessment of Eloquent Function in Brain Tumor Patients
- NCT01542879 · 75 participants · Phase 1
Development of Radiation Free Whole Body Magnetic Resonance (MR) Imaging Technique for Staging Children With Cancer
- NCT02232191 · 75 participants · Phase 2
Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients
- NCT02754544 · 75 participants · NA
Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI