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NCT03598894 · ClinicalTrials.gov registry record
Hypertension Chronobiome
A clinical trial of Hypertension, sponsored by University of Pennsylvania.
- Active
- Registry status
- 150
- Enrollment target
- 1
- Study location
NCT03598894: Active study of Hypertension, sponsored by University of Pennsylvania.
NCT03598894 is a study of Hypertension that is active but no longer recruiting, run by University of Pennsylvania. The registered enrollment target is 150 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03598894, a study of Hypertension, is active but no longer recruiting, sponsored by University of Pennsylvania.
- ACTIVE NOT RECRUITING
- Registry status
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
Hypertension is a common condition with a concomitant burden of stroke, kidney disease and myocardial infarction. Its prevalence in developed societies is increasing as they age, and in less developed countries, as their populations assume aspects of the Western diet and lifestyle. Nocturnal non-dipping hypertension (NDHT) - the failure of blood pressure (BP) to dip at night - is estimated to complicate \~40% of hypertensives and is associated with poor outcomes. Randomized controlled trials have shown that a reduction of daytime systolic blood pressure by as little as 5mmHg on average (towards a target of 140mmHg) translates into a measurable clinical benefit. The peak nocturnal difference may be \~15-20mmHg systolic, illustrating the substantial potential for incremental benefit by adequate blood pressure control across the 24 hour cycle in this population. In this study, the investigators wish (i) to establish through repeated assessment, the stability of the non-dipping phenotype (Phase 1), and (ii) to deeply phenotype non-dippers by using parameters assessing day/night patterns, the chronobiome (Phase 2). To facilitate data collection over the course of the study, the investigators use wearable devices and mobile phone applications.
Primary Outcome
Ambulatory blood pressure measurements (ABPM)
Conditions Studied
Interventions
- OTHER Ambulatory blood pressure measurements
Study Locations (1)
Pennsylvania
- Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2018-07-16 |
| Est. Completion | 2028-05-31 |
What the registry record for NCT03598894 still lists
NCT03598894 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 1 intervention - of which Ambulatory blood pressure measurements is the first listed.
NCT03598894 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT03598894 about?
NCT03598894 is a clinical study titled "Hypertension Chronobiome". Hypertension is a common condition with a concomitant burden of stroke, kidney disease and myocardial infarction. Its prevalence in developed societies is increasing as they age, and in less developed countries, as their populations assume aspects of the Western diet and lifestyle. Nocturnal non-dip...
What is the current status of trial NCT03598894?
This trial is currently active not recruiting. The enrollment target is 150 participants. The study started on 2018-07-16. Estimated completion is 2028-05-31.
What conditions does trial NCT03598894 study?
This clinical trial studies the following conditions: Hypertension.
What interventions are being tested in trial NCT03598894?
The interventions under investigation include: Ambulatory blood pressure measurements (OTHER).
Who is sponsoring clinical trial NCT03598894?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03598894 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03598894's enrollment target sits among peer trials
150 247th of 470 higher than 217 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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