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Stress CMR Perfusion Imaging in the United States (SPINS) Study
NCT03192891 · View on ClinicalTrials.gov ↗
Study Summary
Numerous single-center studies have indicated gadolinium-enhanced stress CMR perfusion imaging has excellent diagnostic accuracy for coronary artery disease and negative clinical event rates, with its diagnostic accuracy exceeding nuclear scintigraphy. However, current prognostic evidence supporting clinical use of stress CMR is limited by study size, single-center settings with a predominance of academic centers, and a lack of "real-world" study design. Large-scale multicenter real-world evidence from a registry will provide the much needed information to guide evidence-based clinical adaptation that benefits patient care.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Stress cardiac magnetic resonance (CMR) perfusion imaging
Study Locations (13)
Illinois
- University of Illinois — Chicago
- University of Chicago — Chicago
Texas
- Houston Methodist — Houston
- San Antonio Military Medical Center - Wilford Hall — San Antonio
California
- Scripps Clinic — La Jolla
Kentucky
- University of Kentucky — Lexington
Maryland
- National Heart, Lung, and Blood Institute (NHLBI) — Bethesda
Massachusetts
- Brigham and Women's Hospital — Boston
Minnesota
- University of Minnesota — Minneapolis
New York
- New York-Presbyterian Brooklyn Methodist Hospital — Brooklyn
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,349 participants |
| Start Date | 2016-12-01 |
| Est. Completion | 2019-11-30 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03192891
The ClinicalTrials.gov registry entry for NCT03192891 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 2,349 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Society for Cardiovascular Magnetic Resonance, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Myocardial Ischemia appearing as the primary indexed condition, and to 1 intervention — of which Stress cardiac magnetic resonance (CMR) perfusion imaging is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03192891 reports 13 study locations spanning 11 distinct geographic areas — top geographies include Illinois, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03192891 about?
NCT03192891 is a clinical study titled "Stress CMR Perfusion Imaging in the United States (SPINS) Study". Numerous single-center studies have indicated gadolinium-enhanced stress CMR perfusion imaging has excellent diagnostic accuracy for coronary artery disease and negative clinical event rates, with its diagnostic accuracy exceeding nuclear scintigraphy. However, current prognostic evidence supporting...
What is the current status of trial NCT03192891?
This trial is currently completed. The enrollment target is 2,349 participants. The study started on 2016-12-01. Estimated completion is 2019-11-30.
What conditions does trial NCT03192891 study?
This clinical trial studies the following conditions: Myocardial Ischemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03192891?
The interventions under investigation include: Stress cardiac magnetic resonance (CMR) perfusion imaging (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03192891?
This trial is sponsored by Society for Cardiovascular Magnetic Resonance, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03192891 being conducted?
This trial has 13 study locations across California, Illinois, Kentucky, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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