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NCT05762952 · ClinicalTrials.gov registry record · Phase 1
Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease
A Phase 1 study of Myocardial Ischemia, sponsored by University of Virginia.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05762952: Recruiting Phase 1 study of Myocardial Ischemia, sponsored by University of Virginia.
NCT05762952 is a Phase 1 study of Myocardial Ischemia that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 40 participants, below the 2,136-participant average among 29 other Myocardial Ischemia trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05762952, a Phase 1 study of Myocardial Ischemia, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to test the effects of a drug (in the drug class called sodium-glucose cotransporter 2 inhibitors) in women who have symptoms of ischemic heart disease. The main questions the study aims to answer are: Does blood flow in the heart improve with study drug? Participants will be randomly assigned to a 12-week course of the study drug, dapagliflozin 10mg, or placebo. Blood flow in the heart will be assessed using stress cardiac magnetic resonance imaging at baseline and 12 weeks. The researchers will compare the results from the two groups.
Primary Outcome
Myocardial microvascular perfusion, defined as myocardial perfusion reserve as assessed by stress cardiac magnetic resonance imaging
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Dapagliflozin 10mg Tab
Study Locations (1)
Virginia
- University of Virginia - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-06-06 |
| Est. Completion | 2026-03-31 |
| Phase | Phase 1 |
What NCT05762952 shows while recruiting
NCT05762952 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 2,136-participant average among 29 other Myocardial Ischemia trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Myocardial Ischemia appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05762952 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT05762952 about?
NCT05762952 is a clinical study titled "Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease". The goal of this clinical trial is to test the effects of a drug (in the drug class called sodium-glucose cotransporter 2 inhibitors) in women who have symptoms of ischemic heart disease. The main questions the study aims to answer are: Does blood flow in the heart improve with study drug? Partici...
What is the current status of trial NCT05762952?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2023-06-06. Estimated completion is 2026-03-31.
What conditions does trial NCT05762952 study?
This clinical trial studies the following conditions: Myocardial Ischemia.
What interventions are being tested in trial NCT05762952?
The interventions under investigation include: Placebo (DRUG), Dapagliflozin 10mg Tab (DRUG).
Who is sponsoring clinical trial NCT05762952?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05762952 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Myocardial Ischemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05762952's enrollment target sits among peer trials
40 25th of 29 higher than 5 of 29 other Myocardial Ischemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Myocardial Ischemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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