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NCT03047746 · ClinicalTrials.gov registry record · NA
Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF
A NA study of Paroxysmal Nocturnal Hemoglobinuria and Inherited Bone Marrow Failure Syndromes, sponsored by Children's Hospital of Philadelphia.
- Active
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT03047746: Active NA study of Paroxysmal Nocturnal Hemoglobinuria and Inherited Bone Marrow Failure Syndromes, sponsored by Children's Hospital of Philadelphia.
NCT03047746 is a NA study of Paroxysmal Nocturnal Hemoglobinuria and Inherited Bone Marrow Failure Syndromes that is active but no longer recruiting, run by Children's Hospital of Philadelphia. The registered enrollment target is 50 participants, below the 261-participant average among 14 other Paroxysmal Nocturnal Hemoglobinuria trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03047746, a NA study of Paroxysmal Nocturnal Hemoglobinuria and Inherited Bone Marrow Failure Syndromes, is active but no longer recruiting, sponsored by Children's Hospital of Philadelphia.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes.
Conditions Studied
Interventions
- DEVICE CliniMACs
Study Locations (1)
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2017-02-01 |
| Est. Completion | 2029-05 |
| Phase | NA |
What the registry record for NCT03047746 still lists
NCT03047746 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 261-participant average among 14 other Paroxysmal Nocturnal Hemoglobinuria trials with a reported enrollment target (81% lower).
The record links to 3 conditions, with Paroxysmal Nocturnal Hemoglobinuria appearing as the primary indexed condition, and to 1 intervention - of which CliniMACs is the first listed.
NCT03047746 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT03047746 about?
NCT03047746 is a clinical study titled "Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF". This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure...
What is the current status of trial NCT03047746?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2017-02-01. Estimated completion is 2029-05.
What conditions does trial NCT03047746 study?
This clinical trial studies the following conditions: Paroxysmal Nocturnal Hemoglobinuria, Inherited Bone Marrow Failure Syndromes, Acquired Aplastic Anemia.
What interventions are being tested in trial NCT03047746?
The interventions under investigation include: CliniMACs (DEVICE).
Who is sponsoring clinical trial NCT03047746?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03047746 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Paroxysmal Nocturnal Hemoglobinuria
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03047746's enrollment target sits among peer trials
50 10th of 14 higher than 3 of 14 other Paroxysmal Nocturnal Hemoglobinuria trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Paroxysmal Nocturnal Hemoglobinuria trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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