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COMPLETED Phase 3

A Study of Atezolizumab Versus Placebo in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Participants With Newly-Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

NCT03038100 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase III, global, double-blind, 2-arm randomized study designed to compare the efficacy and safety of atezolizumab + paclitaxel + carboplatin + bevacizumab versus placebo + paclitaxel + carboplatin + bevacizumab. Study participants will have Stage 3 or 4 ovarian cancer (OC), fallopian tube cancer (FTC), or primary peritoneal cancer (PPC) with macroscopic residual disease postoperatively (i.e., after primary tumor reductive surgery) or who will undergo neoadjuvant therapy followed by interval surgery.

Interventions

  • DRUG Bevacizumab
  • DRUG Carboplatin
  • DRUG Atezolizumab
  • DRUG Paclitaxel
  • DRUG Atezolizumab Placebo

Study Locations (20)

California

  • Moores Cancer Center at UC San Diego Health — La Jolla
  • LAC + USC Medical Center — Los Angeles
  • UCLA - School of Medicine — Los Angeles
  • Kaiser Permanente - Oakland — Oakland
  • The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange — Orange
  • UC Irvine Medical Center — Orange
  • Stanford University — Palo Alto
  • Kaiser Permanente - Sacramento — Roseville
  • Southern California Kaiser Permanente — San Diego
  • California Pacific Medical Center Research Institute — San Francisco
  • K. Permanente - San Fransisco — San Francisco
  • University of California San Francisco Cancer Center — San Francisco
  • Kaiser Permanente - Santa Clara — Santa Clara
  • Olive View/Ucla Medical Center — Sylmar
  • Kaiser Permanente - Walnut Creek — Walnut Creek

Arizona

  • St. Joseph'S Hospital & Medical Center — Phoenix
  • Arizona Oncology Associates, PC - HAL — Scottsdale
  • Arizona Oncology - HOPE Wilmot — Tucson

Colorado

  • University of Colorado Hospital - Anschutz Cancer Pavilion — Aurora

Connecticut

  • Danbury Hospital — Danbury

Trial Details

FieldValue
Enrollment Target 1,301 participants
Start Date 2017-03-08
Est. Completion 2022-08-12
Phase Phase 3

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03038100

The ClinicalTrials.gov registry entry for NCT03038100 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,301 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03038100 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Arizona, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03038100 about?

NCT03038100 is a clinical study titled "A Study of Atezolizumab Versus Placebo in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Participants With Newly-Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer". This is a Phase III, global, double-blind, 2-arm randomized study designed to compare the efficacy and safety of atezolizumab + paclitaxel + carboplatin + bevacizumab versus placebo + paclitaxel + carboplatin + bevacizumab. Study participants will have Stage 3 or 4 ovarian cancer (OC), fallopian tub...

What is the current status of trial NCT03038100?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 1,301 participants. The study started on 2017-03-08. Estimated completion is 2022-08-12.

What conditions does trial NCT03038100 study?

This clinical trial studies the following conditions: Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03038100?

The interventions under investigation include: Bevacizumab (DRUG), Carboplatin (DRUG), Atezolizumab (DRUG), Paclitaxel (DRUG), Atezolizumab Placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03038100?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03038100 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial