Clinical Autonomic Disorders: A Training Protocol

Study Summary

Background: \- The autonomic nervous system helps control things that happen automatically in the body, like blood pressure, heart rate, and digestion. When it doesn t work properly, it s called dysautonomia. Researchers want to learn more about dysautonomias and train doctors to learn how to better diagnose them. Objectives: * To allow people with autonomic disorders to be evaluated. * To help fellows in the NIH Autonomic Disorders fellowship program see a variety of diseases in their training. Eligibility: * People age 18 and older with dysautonomia; children over age 2 if they might benefit * Healthy adult volunteers Design: * Participants will have different procedures depending on their symptoms. They will have one or more visits. They will have some but not all of the tests below. * Participants will have a medical history and physical exam. They may be tested for problems thinking. They may complete a symptom questionnaire. They may have their temperature and blood pressure taken. * Participants may have an intravenous line placed. A needle will guide a thin plastic tube into an arm vein. * Participants may have blood drawn several times. They may give a urine sample. * Participants may have an electrocardiogram. * How much blood a participant s heart is pumping and/or how much blood is flowing through their arm may be measured. The total amount of blood in their bloodstream may be measured. * Participants may have their ability to sweat and/or sense of smell tested. * Breathing, bowel sounds, and/or body functions may be monitored. * Pupil size, response to environmental temperature changes, and/or breathing may be measured. * Participants may have a bladder ultrasound. * Small pieces of skin may be taken for study.