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NCT07100990 · ClinicalTrials.gov registry record · Phase 3

Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

A Phase 3 study of Optic Neuritis and Myelitis, Transverse, sponsored by Mayo Clinic.

Recruiting
Registry status
Phase 3
Development phase
382
Enrollment target
20
Study locations

NCT07100990 is a Phase 3 study of Optic Neuritis and Myelitis, Transverse that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 382 participants, below the 728-participant average among 5 other Optic Neuritis trials with a reported enrollment target (48% lower). The trial reports 20 study locations across 16 states.

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The verdict

NCT07100990, a Phase 3 study of Optic Neuritis and Myelitis, Transverse, is actively recruiting participants, sponsored by Mayo Clinic.

RECRUITING
Registry status
Phase 3
Development phase
382 participants
Enrollment target
20
Study locations

Study Summary

The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes in severe Transverse Myelitis.

Conditions Studied

Optic Neuritis Myelitis, Transverse Myelitis

Interventions

  • DRUG High-dose corticosteroids (HDCS)
  • DRUG High-dose corticosteroids (HDCS) and PLEX

Study Locations (20)

Illinois

  • University of Illinois Chicago - Chicago
  • Northwestern University - Evanston

Maryland

  • University of Maryland, Baltimore - Baltimore
  • Johns Hopkins University - Baltimore

Massachusetts

  • Harvard University Massachusetts General Hospital - Boston
  • Boston Medical Center - Boston

New York

  • Icahn School of Medicine at Mount Sinai - New York
  • Weill Cornell Medical College - New York

Arizona

  • Mayo Clinic Arizona - Scottsdale

Colorado

  • University of Colorado - Anschutz Medical - Aurora

Connecticut

  • Yale University School of Medicine - North Haven

Florida

  • Mayo Clinic Florida - Jacksonville

Trial Details

FieldValue
Enrollment Target 382 participants
Start Date 2025-07-11
Est. Completion 2031-04-30
Phase Phase 3

Sponsor

Mayo Clinic

2,844 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07100990

The ClinicalTrials.gov registry entry for NCT07100990 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 382 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 728-participant average among 5 other Optic Neuritis trials with a reported enrollment target (48% lower). The listed sponsor is Mayo Clinic, which has 2,844 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Optic Neuritis appearing as the primary indexed condition, and to 2 interventions - of which High-dose corticosteroids (HDCS) is the first listed.

NCT07100990 reports 20 study locations spanning 16 distinct geographic areas - top geographies include Illinois, Maryland, Massachusetts.

Frequently Asked Questions

What is clinical trial NCT07100990 about?

NCT07100990 is a clinical study titled "Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)". The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes in severe Transverse Myelitis.

What is the current status of trial NCT07100990?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 382 participants. The study started on 2025-07-11. Estimated completion is 2031-04-30.

What conditions does trial NCT07100990 study?

This clinical trial studies the following conditions: Optic Neuritis, Myelitis, Transverse, Myelitis.

What interventions are being tested in trial NCT07100990?

The interventions under investigation include: High-dose corticosteroids (HDCS) (DRUG), High-dose corticosteroids (HDCS) and PLEX (DRUG).

Who is sponsoring clinical trial NCT07100990?

This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07100990 being conducted?

This trial has 20 study locations across Arizona, Colorado, Connecticut, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.