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NCT01896934 · ClinicalTrials.gov registry record · Phase 4
Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression
A Phase 4 study of Major Depressive Disorder, sponsored by Vanderbilt University.
- Completed
- Registry status
- Phase 4
- Development phase
- 31
- Enrollment target
- 1
- Study location
NCT01896934: Completed Phase 4 study of Major Depressive Disorder, sponsored by Vanderbilt University.
NCT01896934 is a Phase 4 study of Major Depressive Disorder that has completed, run by Vanderbilt University. The registered enrollment target is 31 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01896934, a Phase 4 study of Major Depressive Disorder, has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 31 participants
- Enrollment target
- 1
- Study location
Study Summary
The long-term goal of this line of research is to determine if decreased vascular reactivity and frontal hypoperfusion is associated with poor response antidepressants. Such perfusion deficits could contribute to antidepressant nonresponse as they would hinder improvements in dorsal system metabolism seen with antidepressant treatment. The objective of the current proposal is to determine if decreased vascular reactivity and frontal hypoperfusion in depressed elders predicts and persists with antidepressant nonremission. The investigators will pursue the primary aim testing the hypothesis that decreased reactivity and hypoperfusion, specifically in the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex, predict antidepressant nonremission. The investigators will enroll 40 depressed elders who will complete clinical, cognitive, and MRI assessments before and after a 12-week open-label antidepressant trial of sertraline.
Primary Outcome
Montgomery-Asberg Depression Rating Scale (MADRS) is a measure of depression severity. This will be used to define remission as a score of 7 or less.
Conditions Studied
Interventions
- DRUG Sertraline
Study Locations (1)
Tennessee
- Vanderbilt University - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2013-07 |
| Est. Completion | 2016-06 |
| Phase | Phase 4 |
What the finished NCT01896934 record still lists
NCT01896934 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention - of which Sertraline is the first listed.
NCT01896934 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT01896934 about?
NCT01896934 is a clinical study titled "Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression". The long-term goal of this line of research is to determine if decreased vascular reactivity and frontal hypoperfusion is associated with poor response antidepressants. Such perfusion deficits could contribute to antidepressant nonresponse as they would hinder improvements in dorsal system metabolis...
What is the current status of trial NCT01896934?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 31 participants. The study started on 2013-07. Estimated completion is 2016-06.
What conditions does trial NCT01896934 study?
This clinical trial studies the following conditions: Major Depressive Disorder.
What interventions are being tested in trial NCT01896934?
The interventions under investigation include: Sertraline (DRUG).
Who is sponsoring clinical trial NCT01896934?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01896934 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01896934's enrollment target sits among peer trials
31 219th of 282 higher than 64 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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