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ACTIVE NOT RECRUITING Phase 3

Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma

NCT04987203 · View on ClinicalTrials.gov ↗

Study Summary

This study will be comparing tivozanib in combination with nivolumab to tivozanib alone in subjects with advanced Renal Cell Carcinoma (RCC) who have had 1 or 2 prior lines of therapy, one of which was an Immune Checkpoint Inhibitor (ICI).

Conditions Studied

Interventions

  • DRUG Nivolumab
  • DRUG Tivozanib

Study Locations (20)

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • Chao Family Comprehensive Cancer Center, UC Irvine — Irvine
  • University of California San Diego — La Jolla
  • Leland Stanford Junior University — Redwood City
  • Kaiser Permanente Riverside Medical Center — Riverside

Maryland

  • University of Maryland Medical Center-Greenebaum Cancer Ctr — Baltimore
  • John Hopkins Medicine - Hematology/oncology — Baltimore
  • Maryland Oncology Hematology — Clinton

Florida

  • Florida Cancer Specialists & Res Inst — Fort Myers
  • Florida Cancer Specialists & Research Institute (FCS) - Tampa Cancer Center Location — St. Petersburg

Colorado

  • US Oncology - Rocky Mountain Cancer Centers - Midtown — Denver

Kansas

  • The University of Kansas Cancer Center — Westwood

Kentucky

  • University of Kentucky UK Markey Cancer Center — Lexington

Louisiana

  • Tulane Cancer Center Clinic - Oncology — New Orleans

Massachusetts

  • Dana-Farber Cancer Institute - Medicine — Boston

Trial Details

FieldValue
Enrollment Target 343 participants
Start Date 2021-09-09
Est. Completion 2025-12-30
Phase Phase 3

Sponsor

AVEO Pharmaceuticals

33 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04987203

The ClinicalTrials.gov registry entry for NCT04987203 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 343 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AVEO Pharmaceuticals, which has 33 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Renal Cell Carcinoma appearing as the primary indexed condition, and to 2 interventions — of which Nivolumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04987203 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, Maryland, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04987203 about?

NCT04987203 is a clinical study titled "Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma". This study will be comparing tivozanib in combination with nivolumab to tivozanib alone in subjects with advanced Renal Cell Carcinoma (RCC) who have had 1 or 2 prior lines of therapy, one of which was an Immune Checkpoint Inhibitor (ICI).

What is the current status of trial NCT04987203?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 343 participants. The study started on 2021-09-09. Estimated completion is 2025-12-30.

What conditions does trial NCT04987203 study?

This clinical trial studies the following conditions: Renal Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04987203?

The interventions under investigation include: Nivolumab (DRUG), Tivozanib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04987203?

This trial is sponsored by AVEO Pharmaceuticals, which has 33 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04987203 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Kansas, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial