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NCT04987203 · ClinicalTrials.gov registry record · Phase 3
Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma
A Phase 3 study of Renal Cell Carcinoma, sponsored by AVEO Pharmaceuticals.
- Active
- Registry status
- Phase 3
- Development phase
- 343
- Enrollment target
- 20
- Study locations
NCT04987203 is a Phase 3 study of Renal Cell Carcinoma that is active but no longer recruiting, run by AVEO Pharmaceuticals. The registered enrollment target is 343 participants, above the 240-participant average among 121 other Renal Cell Carcinoma trials with a reported enrollment target (43% higher). The trial reports 20 study locations across 13 states.
The verdict
NCT04987203, a Phase 3 study of Renal Cell Carcinoma, is active but no longer recruiting, sponsored by AVEO Pharmaceuticals.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 343 participants
- Enrollment target
- 20
- Study locations
Study Summary
This study will be comparing tivozanib in combination with nivolumab to tivozanib alone in subjects with advanced Renal Cell Carcinoma (RCC) who have had 1 or 2 prior lines of therapy, one of which was an Immune Checkpoint Inhibitor (ICI).
Conditions Studied
Interventions
- DRUG Nivolumab
- DRUG Tivozanib
Study Locations (20)
California
- City of Hope Comprehensive Cancer Center - Duarte
- Chao Family Comprehensive Cancer Center, UC Irvine - Irvine
- University of California San Diego - La Jolla
- Leland Stanford Junior University - Redwood City
- Kaiser Permanente Riverside Medical Center - Riverside
Maryland
- University of Maryland Medical Center-Greenebaum Cancer Ctr - Baltimore
- John Hopkins Medicine - Hematology/oncology - Baltimore
- Maryland Oncology Hematology - Clinton
Florida
- Florida Cancer Specialists & Res Inst - Fort Myers
- Florida Cancer Specialists & Research Institute (FCS) - Tampa Cancer Center Location - St. Petersburg
Colorado
- US Oncology - Rocky Mountain Cancer Centers - Midtown - Denver
Kansas
- The University of Kansas Cancer Center - Westwood
Kentucky
- University of Kentucky UK Markey Cancer Center - Lexington
Louisiana
- Tulane Cancer Center Clinic - Oncology - New Orleans
Massachusetts
- Dana-Farber Cancer Institute - Medicine - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 343 participants |
| Start Date | 2021-09-09 |
| Est. Completion | 2025-12-30 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04987203
The ClinicalTrials.gov registry entry for NCT04987203 describes a study currently listed as active not recruiting, categorized as Phase 3. The registered enrollment target is 343 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 240-participant average among 121 other Renal Cell Carcinoma trials with a reported enrollment target (43% higher). The listed sponsor is AVEO Pharmaceuticals, which has 27 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Renal Cell Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Nivolumab is the first listed.
NCT04987203 reports 20 study locations spanning 13 distinct geographic areas - top geographies include California, Maryland, Florida.
Frequently Asked Questions
What is clinical trial NCT04987203 about?
NCT04987203 is a clinical study titled "Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma". This study will be comparing tivozanib in combination with nivolumab to tivozanib alone in subjects with advanced Renal Cell Carcinoma (RCC) who have had 1 or 2 prior lines of therapy, one of which was an Immune Checkpoint Inhibitor (ICI).
What is the current status of trial NCT04987203?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 343 participants. The study started on 2021-09-09. Estimated completion is 2025-12-30.
What conditions does trial NCT04987203 study?
This clinical trial studies the following conditions: Renal Cell Carcinoma.
What interventions are being tested in trial NCT04987203?
The interventions under investigation include: Nivolumab (DRUG), Tivozanib (DRUG).
Who is sponsoring clinical trial NCT04987203?
This trial is sponsored by AVEO Pharmaceuticals, which has 27 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04987203 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Kansas, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.