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NCT01205672 · ClinicalTrials.gov registry record · Early Phase 1
Evaluation of the Molecular Effects of Metformin on the Endometrium in Patients With Endometrial Cancer
A Early Phase 1 study of Endometrial Cancer, sponsored by M.D. Anderson Cancer Center.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 21
- Enrollment target
- 2
- Study locations
NCT01205672 is a Early Phase 1 study of Endometrial Cancer that has completed, run by M.D. Anderson Cancer Center. The registered enrollment target is 21 participants, below the 524-participant average among 181 other Endometrial Cancer trials with a reported enrollment target (96% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT01205672, a Early Phase 1 study of Endometrial Cancer, has completed, sponsored by M.D. Anderson Cancer Center.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 21 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this research study is to learn if metformin can affect endometrial cancer cells in women who do not have diabetes. Objectives: Primary Objectives: 1\. To determine the molecular effects of metformin and associated physiologic changes in insulin/glucose metabolism on the mTOR (mammalian target of rapamycin) signaling pathway in the endometrium of women with endometrial cancer Secondary Objectives: 1. To describe the effects of metformin on the histology and proliferation of the endometrium in women with endometrial cancer. 2. To assess the effect of body mass index on the response to treatment with metformin 3. To assess the effect of insulin resistance on the response to treatment with metformin 4. To determine effects of metformin on the serum, urine and DNA biomarkers of women with endometrial cancer.
Conditions Studied
Interventions
- DRUG Metformin
Study Locations (2)
Texas
- Lyndon B. Johnson General Hospital - Houston
- University of Texas MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2010-09-16 |
| Est. Completion | 2017-05-28 |
| Phase | Early Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01205672
The ClinicalTrials.gov registry entry for NCT01205672 describes a study currently listed as completed, categorized as Early Phase 1. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 524-participant average among 181 other Endometrial Cancer trials with a reported enrollment target (96% lower). The listed sponsor is M.D. Anderson Cancer Center, which has 2,692 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Endometrial Cancer appearing as the primary indexed condition, and to 1 intervention - of which Metformin is the first listed.
NCT01205672 reports 2 study locations spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT01205672 about?
NCT01205672 is a clinical study titled "Evaluation of the Molecular Effects of Metformin on the Endometrium in Patients With Endometrial Cancer". The goal of this research study is to learn if metformin can affect endometrial cancer cells in women who do not have diabetes. Objectives: Primary Objectives: 1\. To determine the molecular effects of metformin and associated physiologic changes in insulin/glucose metabolism on the mTOR (mammali...
What is the current status of trial NCT01205672?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 21 participants. The study started on 2010-09-16. Estimated completion is 2017-05-28.
What conditions does trial NCT01205672 study?
This clinical trial studies the following conditions: Endometrial Cancer.
What interventions are being tested in trial NCT01205672?
The interventions under investigation include: Metformin (DRUG).
Who is sponsoring clinical trial NCT01205672?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01205672 being conducted?
This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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