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NCT00645645 · ClinicalTrials.gov registry record
A Study of the Genetic Analysis of Brain Disorders
A clinical trial of Holoprosencephaly, sponsored by National Human Genome Research Institute (NHGRI).
- Completed
- Registry status
- 5,735
- Enrollment target
- 1
- Study location
NCT00645645 is a study of Holoprosencephaly that has completed, run by National Human Genome Research Institute (NHGRI). The registered enrollment target is 5,735 participants. The trial reports 1 study location across 1 state.
The verdict
NCT00645645, a study of Holoprosencephaly, has completed, sponsored by National Human Genome Research Institute (NHGRI).
- COMPLETED
- Registry status
- 5,735 participants
- Enrollment target
- 1
- Study location
Study Summary
A study of the complex genetics of brain development will be undertaken with an emphasis on those genes that cause the most common structural brain anomaly in humans called holoprosencephaly (HPE). This malformation of the brain can result from either environmental or genetic causes, and it is the aim of these investigations to determine the genes responsible for both normal and abnormal brain development through the study of patients with this disorder. Mutations in one such gene, Sonic Hedgehog, have been shown by us to be responsible for approximately one quarter of familial cases of HPE. Other genes either related to the hedgehog pathway or located at unrelated defined genetic loci may also contribute to HPE and are the subject of active investigation. We anticipate that many genes important for normal brain development will be identified in the search for genetic causes of HPE.
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5,735 participants |
| Start Date | 2008-06-01 |
| Est. Completion | 2021-01-19 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00645645
The ClinicalTrials.gov registry entry for NCT00645645 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 5,735 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Human Genome Research Institute (NHGRI), which has 185 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Holoprosencephaly appearing as the primary indexed condition, and to 0 interventions.
NCT00645645 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT00645645 about?
NCT00645645 is a clinical study titled "A Study of the Genetic Analysis of Brain Disorders". A study of the complex genetics of brain development will be undertaken with an emphasis on those genes that cause the most common structural brain anomaly in humans called holoprosencephaly (HPE). This malformation of the brain can result from either environmental or genetic causes, and it is the a...
What is the current status of trial NCT00645645?
This trial is currently completed. The enrollment target is 5,735 participants. The study started on 2008-06-01. Estimated completion is 2021-01-19.
What conditions does trial NCT00645645 study?
This clinical trial studies the following conditions: Holoprosencephaly.
Who is sponsoring clinical trial NCT00645645?
This trial is sponsored by National Human Genome Research Institute (NHGRI), which has 185 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00645645 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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