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NCT00573859 · ClinicalTrials.gov registry record · Phase 1
The Reinforcing Mechanisms of Smoking in Adult ADHD
A Phase 1 study of ADHD, sponsored by University of California, Irvine.
- Completed
- Registry status
- Phase 1
- Development phase
- 27
- Enrollment target
- 1
- Study location
NCT00573859: Completed Phase 1 study of ADHD, sponsored by University of California, Irvine.
NCT00573859 is a Phase 1 study of ADHD that has completed, run by University of California, Irvine. The registered enrollment target is 27 participants, below the 190-participant average among 75 other ADHD trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00573859, a Phase 1 study of ADHD, has completed, sponsored by University of California, Irvine.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 27 participants
- Enrollment target
- 1
- Study location
Study Summary
Whereas the smoking prevalence rates in the general population are declining, rates among people diagnosed with attention-deficit hyperactivity disorder (ADHD) continue to be elevated. Smoking may be a form of self-medication in people with ADHD, which has specific reinforcing mechanisms such as improvement of ADHD core symptoms, enhancement of moods and arousal, or a combination of both. In addition, the reinforcing effects of smoking may be potentiated by stimulant medication. The study examined the reinforcing effects of ad libitum smoking with and without ADHD medication in adult smokers with clinically diagnosed ADHD. Participants were adults with ADHD. The effects of two day of ADHD medication compared to two days on placebo for were studied on nicotine intake (i.e., cotinine levels). In addition, task performance on the Continuous Performance Task and nicotine withdrawal symptoms were examined in response to ADHD medication + smoking a cigarette versus ADHD medication + abstinence versus placebo medication + smoking versus placebo medication + abstinence. The study identified the reinforcing mechanisms of smoking in interaction with ADHD medication. The findings will contribute to a better understanding of nicotine addiction and facilitate the development of targeted smoking cessation and prevention programs for individuals with ADHD and other people with deficiencies in impulse control and excessive risk taking.
Primary Outcome
Salivary cotinine was measured across two days on ADHD medication versus two days on placebo.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG ADHD medication
Study Locations (1)
California
- Department of Pediatrics - Irvine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2006-09 |
| Est. Completion | 2010-06 |
| Phase | Phase 1 |
What the finished NCT00573859 record still lists
NCT00573859 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 190-participant average among 75 other ADHD trials with a reported enrollment target (86% lower).
The record links to 1 condition, with ADHD appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT00573859 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00573859 about?
NCT00573859 is a clinical study titled "The Reinforcing Mechanisms of Smoking in Adult ADHD". Whereas the smoking prevalence rates in the general population are declining, rates among people diagnosed with attention-deficit hyperactivity disorder (ADHD) continue to be elevated. Smoking may be a form of self-medication in people with ADHD, which has specific reinforcing mechanisms such as imp...
What is the current status of trial NCT00573859?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 27 participants. The study started on 2006-09. Estimated completion is 2010-06.
What conditions does trial NCT00573859 study?
This clinical trial studies the following conditions: ADHD.
What interventions are being tested in trial NCT00573859?
The interventions under investigation include: Placebo (DRUG), ADHD medication (DRUG).
Who is sponsoring clinical trial NCT00573859?
This trial is sponsored by University of California, Irvine, which has 368 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00573859 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00573859's enrollment target sits among peer trials
27 65th of 75 higher than 11 of 75 other ADHD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other ADHD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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