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NCT04707729 · ClinicalTrials.gov registry record · NA
ROX Index for the Timing of Intubation in Nasal High Flow
A NA study of Acute Hypoxemic Respiratory Failure, sponsored by Hospital Universitari Vall d'Hebron Research Institute.
- Recruiting
- Registry status
- NA
- Development phase
- 630
- Enrollment target
- 12
- Study locations
NCT04707729: Recruiting NA study of Acute Hypoxemic Respiratory Failure, sponsored by Hospital Universitari Vall d'Hebron Research Institute.
NCT04707729 is a NA study of Acute Hypoxemic Respiratory Failure that is actively recruiting participants, run by Hospital Universitari Vall d'Hebron Research Institute. The registered enrollment target is 630 participants, below the 845-participant average among 5 other Acute Hypoxemic Respiratory Failure trials with a reported enrollment target (25% lower). The trial reports 12 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04707729, a NA study of Acute Hypoxemic Respiratory Failure, is actively recruiting participants, sponsored by Hospital Universitari Vall d'Hebron Research Institute.
- RECRUITING
- Registry status
- NA
- Development phase
- 630 participants
- Enrollment target
- 12
- Study locations
Study Summary
Late or delayed intubation in patients with acute hypoxemic respiratory failure (AHRF) treated with nasal high flow (NHF) is associated with increased patient mortality. The ROX index has been designed and validated to predict outcome of NFH therapy by identifying those patients with a high risk of NHF failure and those with a high probability of success. Whether or not the ROX index may improve patient outcome remains to be shown. To do so, a strategy using the ROX index must lead to earlier intubation than commonly-used criteria. The objective of the ROX-1 trial is to assess whether the use of an algorithm incorporating the ROX index to standard of care for the time to intubation in patients with AHRF supported with NHF isassociated with an increase in the proportion of patients who are intubated within the first 12 hours among those patients who fail on NHF.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST ROX index algorithm
Study Locations (12)
Other
- First Affiliated Hospital of Chongqing Medical University - Chongqing
- The Second Military Medical University Hospital - Shanghai
- Zhongshan Hospital, Fudan University - Shanghai
- Hospital Universitari Vall d'Hebron - Barcelona
- Hospital del Mar - Barcelona
- Hospital de Ciudad Real - Ciudad Real
- Hospital Civil Fray Antonio Alcalde - Guadalajara
- Hospital Son Llàtzer - Palma de Mallorca
- Hospital Parc Taulí - Sabadell
- Hospital Moisès Broggi - Sant Joan Despí
- Hospital Virgen de la Salud - Toledo
Illinois
- Rush University Chicago Hospital - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 630 participants |
| Start Date | 2020-12-09 |
| Est. Completion | 2025-06-30 |
| Phase | NA |
What NCT04707729 shows while recruiting
NCT04707729 is an interventional study that assigns participants to a tested intervention. The registered 630 participants enrollment target is mid-sized for trials with a published cap, below the 845-participant average among 5 other Acute Hypoxemic Respiratory Failure trials with a reported enrollment target (25% lower).
The record links to 1 condition, with Acute Hypoxemic Respiratory Failure appearing as the primary indexed condition, and to 1 intervention - of which ROX index algorithm is the first listed.
NCT04707729 lists 12 locations in 2 states (Other, Illinois).
Frequently Asked Questions
What is clinical trial NCT04707729 about?
NCT04707729 is a clinical study titled "ROX Index for the Timing of Intubation in Nasal High Flow". Late or delayed intubation in patients with acute hypoxemic respiratory failure (AHRF) treated with nasal high flow (NHF) is associated with increased patient mortality. The ROX index has been designed and validated to predict outcome of NFH therapy by identifying those patients with a high risk of ...
What is the current status of trial NCT04707729?
This trial is currently recruiting. It is a NA study. The enrollment target is 630 participants. The study started on 2020-12-09. Estimated completion is 2025-06-30.
What conditions does trial NCT04707729 study?
This clinical trial studies the following conditions: Acute Hypoxemic Respiratory Failure.
What interventions are being tested in trial NCT04707729?
The interventions under investigation include: ROX index algorithm (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04707729?
This trial is sponsored by Hospital Universitari Vall d'Hebron Research Institute, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04707729 being conducted?
This trial has 12 study locations across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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