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NCT02561988 · ClinicalTrials.gov registry record · Phase 1
(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies
A Phase 1 study, sponsored by Blueprint Medicines Corporation.
- Completed
- Registry status
- Phase 1
- Development phase
- 86
- Enrollment target
NCT02561988 is a Phase 1 study that has completed, run by Blueprint Medicines Corporation. The registered enrollment target is 86 participants.
The verdict
NCT02561988, a Phase 1 study, has completed, sponsored by Blueprint Medicines Corporation.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 86 participants
- Enrollment target
Study Summary
This is a Phase 1, open-label, dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antineoplastic activity of avapritinib (also known as BLU-285), administered orally (PO), in adult patients with advanced systemic mastocytosis and other relapsed or refractory myeloid malignancies. The study consists of 2 parts:, dose-escalation (Part 1) and expansion (Part 2).
Interventions
- DRUG Avapritinib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 86 participants |
| Start Date | 2016-03-10 |
| Est. Completion | 2023-01-19 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02561988
The ClinicalTrials.gov registry entry for NCT02561988 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 86 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Blueprint Medicines Corporation, which has 24 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Avapritinib is the first listed.
NCT02561988 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02561988 about?
NCT02561988 is a clinical study titled "(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies". This is a Phase 1, open-label, dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antineoplastic activity of avapritinib (also known as BLU-285), administered orally (PO), in adult patients with advanced systemic mastocytosis and oth...
What is the current status of trial NCT02561988?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 86 participants. The study started on 2016-03-10. Estimated completion is 2023-01-19.
What interventions are being tested in trial NCT02561988?
The interventions under investigation include: Avapritinib (DRUG).
Who is sponsoring clinical trial NCT02561988?
This trial is sponsored by Blueprint Medicines Corporation, which has 24 total clinical trials registered on ClinicalTrials.gov.
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