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NCT04862780 · ClinicalTrials.gov registry record · Phase 1
(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC
A Phase 1 study, sponsored by Blueprint Medicines Corporation.
- Terminated
- Registry status
- Phase 1
- Development phase
- 177
- Enrollment target
NCT04862780: Clinical Trial Phase 1 study, sponsored by Blueprint Medicines Corporation.
NCT04862780 is a Phase 1 study that was terminated before completion, run by Blueprint Medicines Corporation. The registered enrollment target is 177 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (195% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04862780, a Phase 1 study, was terminated before completion, sponsored by Blueprint Medicines Corporation.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 177 participants
- Enrollment target
Study Summary
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-945, a selective EGFR inhibitor, as monotherapy or in combination with osimertinib.
Primary Outcome
MTD determination: dose limiting toxicity (DLT) rate
Interventions
- DRUG osimertinib
- DRUG BLU-945
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 177 participants |
| Start Date | 2021-06-29 |
| Est. Completion | 2024-10-07 |
| Phase | Phase 1 |
Why NCT04862780 stopped before completion
NCT04862780 is an interventional study that assigns participants to a tested intervention. The registered 177 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (195% higher).
The record links to 0 conditions, and to 2 interventions - of which osimertinib is the first listed.
NCT04862780 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04862780 about?
NCT04862780 is a clinical study titled "(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC". This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-945, a selective EGFR inhibitor, as monotherapy or in combination with osimertinib.
What is the current status of trial NCT04862780?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 177 participants. The study started on 2021-06-29. Estimated completion is 2024-10-07.
What interventions are being tested in trial NCT04862780?
The interventions under investigation include: osimertinib (DRUG), BLU-945 (DRUG).
Who is sponsoring clinical trial NCT04862780?
This trial is sponsored by Blueprint Medicines Corporation, which has 24 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04862780's enrollment target sits among peer trials
177 313th of 2000 higher than 1,685 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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