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NCT04908176 · ClinicalTrials.gov registry record · Phase 1
A Drug-drug Interaction Study of Avapritinib and Midazolam
A Phase 1 study, sponsored by Blueprint Medicines Corporation.
- Completed
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
NCT04908176: Completed Phase 1 study, sponsored by Blueprint Medicines Corporation.
NCT04908176 is a Phase 1 study that has completed, run by Blueprint Medicines Corporation. The registered enrollment target is 10 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04908176, a Phase 1 study, has completed, sponsored by Blueprint Medicines Corporation.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
Study Summary
The purpose of this study is to investigate the effect of multiple dosing of avapritinib on the pharmacokinetics (PK) of midazolam in adult patients with metastatic or unresectable gastrointestinal stromal tumors (GIST), recurrent gliomas, or other KIT mutant tumors.
Interventions
- DRUG Avapritinib
- DRUG midazolam
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-08-24 |
| Est. Completion | 2024-05-10 |
| Phase | Phase 1 |
What the finished NCT04908176 record still lists
NCT04908176 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 2 interventions - of which Avapritinib is the first listed.
NCT04908176 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04908176 about?
NCT04908176 is a clinical study titled "A Drug-drug Interaction Study of Avapritinib and Midazolam". The purpose of this study is to investigate the effect of multiple dosing of avapritinib on the pharmacokinetics (PK) of midazolam in adult patients with metastatic or unresectable gastrointestinal stromal tumors (GIST), recurrent gliomas, or other KIT mutant tumors.
What is the current status of trial NCT04908176?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2022-08-24. Estimated completion is 2024-05-10.
What interventions are being tested in trial NCT04908176?
The interventions under investigation include: Avapritinib (DRUG), midazolam (DRUG).
Who is sponsoring clinical trial NCT04908176?
This trial is sponsored by Blueprint Medicines Corporation, which has 24 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04908176's enrollment target sits among peer trials
10 1913th of 2000 higher than 46 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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