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NCT05252416 · ClinicalTrials.gov registry record · Phase 1
(VELA) Study of BLU-222 in Advanced Solid Tumors
A Phase 1 study, sponsored by Blueprint Medicines Corporation.
- Terminated
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
NCT05252416: Clinical Trial Phase 1 study, sponsored by Blueprint Medicines Corporation.
NCT05252416 is a Phase 1 study that was terminated before completion, run by Blueprint Medicines Corporation. The registered enrollment target is 50 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05252416, a Phase 1 study, was terminated before completion, sponsored by Blueprint Medicines Corporation.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
Study Summary
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-222, a selective inhibitor of CDK2.
Interventions
- DRUG Carboplatin
- DRUG Fulvestrant
- DRUG Ribociclib
- DRUG BLU-222
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2022-04-07 |
| Est. Completion | 2025-07-04 |
| Phase | Phase 1 |
Why NCT05252416 stopped before completion
NCT05252416 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% lower).
The record links to 0 conditions, and to 4 interventions - of which Carboplatin is the first listed.
NCT05252416 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05252416 about?
NCT05252416 is a clinical study titled "(VELA) Study of BLU-222 in Advanced Solid Tumors". This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-222, a selective inhibitor of CDK2.
What is the current status of trial NCT05252416?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2022-04-07. Estimated completion is 2025-07-04.
What interventions are being tested in trial NCT05252416?
The interventions under investigation include: Carboplatin (DRUG), Fulvestrant (DRUG), Ribociclib (DRUG), BLU-222 (DRUG).
Who is sponsoring clinical trial NCT05252416?
This trial is sponsored by Blueprint Medicines Corporation, which has 24 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05252416's enrollment target sits among peer trials
50 973rd of 2000 higher than 984 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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