Astex Pharmaceuticals

38 total trials 29 completed

Astex Pharmaceuticals sponsors 38 registered US clinical trials on ClinicalTrials.gov, none currently recruiting, and 29 completed. 5 of these trials are in Phase 3-4 (later-stage) and 32 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Chronic Myelogenous Leukemia, with 1 trials.

Trial Pipeline

38 total, page 1 of 1

TERMINATED Phase 2

A Study of Oral Decitabine/Cedazuridine in Combination With Magrolimab in Participants With Intermediate- to Very High-Risk Myelodysplastic Syndromes (MDS)

NCT05835011

TERMINATED Phase 1

A Study of TAS1553 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia (AML) and Other Myeloid Neoplasms

NCT04637009

COMPLETED Phase 1

A Phase 1 Study to Evaluate the Effect of Food on Pharmacokinetics of ASTX029

NCT04466514

COMPLETED Phase 1

Effect of Food on the Pharmacokinetics of ASTX660 in Healthy Volunteers

NCT04479800

TERMINATED Phase 1

A Study of ASTX660 as a Single Agent and in Combination With ASTX727 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML)

NCT04155580

COMPLETED Phase 1

A Study to Investigate the Effect of CYP3A4 Inhibition on the Single Dose Pharmacokinetics of ASTX660 and the Effect of a Single Dose of ASTX660 on the Pharmacokinetics of the CYP3A4 Substrate Midazolam

NCT04411030

COMPLETED Phase 1

Effect of Food on Blood Levels of ASTX727

NCT03813186

TERMINATED Phase 2

Guadecitabine Extension Study

NCT03603964

COMPLETED Phase 3

Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML

NCT03306264

COMPLETED Phase 3

Phase 3 Randomized, Open-Label Study of Guadecitabine vs Treatment Choice in Previously Treated Acute Myeloid Leukemia

NCT02920008

COMPLETED Phase 3

Guadecitabine (SGI-110) vs Treatment Choice in Adults With MDS or CMML Previously Treated With HMAs

NCT02907359

COMPLETED Phase 3

SGI-110 in Adults With Untreated Acute Myeloid Leukemia (AML), Not Considered Candidates for Intensive Remission Induction

NCT02348489

COMPLETED Phase 1

Pharmacokinetic Guided Dose Escalation and Dose Confirmation With Oral Decitabine and Oral Cytidine Deaminase Inhibitor (CDAi) in Patients With Myelodysplastic Syndromes (MDS)

NCT02103478

COMPLETED Phase 2

SGI-110 in the Treatment of Advanced Hepatocellular Carcinoma (HCC)

NCT01752933

COMPLETED Phase 1

A Study of AT13387 in Patients With Non-Small Cell Lung Cancer (NSCLC) Alone and in Combination With Crizotinib

NCT01712217

COMPLETED Phase 1

A Study of HSP90 Inhibitor AT13387 Alone or in Combination With Abiraterone Acetate

NCT01685268

COMPLETED Phase 2

SGI-110 in Combination With Carboplatin in Ovarian Cancer

NCT01696032

COMPLETED Phase 2

A Phase 2, Open-Label Study of Amuvatinib in Combination With Platinum-Etoposide Chemotherapy in Small Cell Lung Cancer

NCT01357395

COMPLETED Phase 2

A Study to Investigate the Safety and Efficacy of AT13387, Alone or in Combination With Imatinib, in Patients With GIST

NCT01294202

COMPLETED Phase 1

SGI-110 in Participants With Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML)

NCT01261312

COMPLETED Phase 1

Effect of AT7519M Alone and AT7519M Plus Bortezomib in Patients With Previously Treated Multiple Myeloma

NCT01183949

TERMINATED Phase 1

Safety of SGI-1776, A PIM Kinase Inhibitor in Refractory Prostate Cancer and Relapsed/Refractory Non Hodgkin's Lymphoma

NCT00848601

COMPLETED Phase 1

Study to Assess the Safety of Escalating Doses of AT13387 in Patients With Metastatic Solid Tumors

NCT00878423

COMPLETED Phase 1

Safety of MP470 in Combination With Standard-of-Care Chemotherapy Regimens to Treat Solid Tumors

NCT00881166

COMPLETED Phase 1

Safety Study to Determine the Maximum Tolerated Dose, Pharmacokinetics and Pharmacodynamics of Oral MP470, a Multitargeted Tyrosine Kinase Inhibitor, in Patients With Solid Malignancies

NCT00894894

TERMINATED NA

MP470 in Treating Patients With Unresectable or Metastatic Solid Tumor or Lymphoma

NCT00504205

TERMINATED Phase 1

Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemias

NCT00522990

TERMINATED Phase 2

Orathecin + Gemcitabine Versus Placebo + Gemcitabine in Chemonaive Non-Resectable Pancreatic Cancer

NCT00113256

COMPLETED Phase 2

Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Accelerated Phase Who Are Refractory to Imatinib Mesylate (Gleevec)

NCT00041990

COMPLETED Phase 2

Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Blast Phase Who Are Refractory to Imatinib Mesylate (Gleevec)

NCT00042003

COMPLETED Phase 2

Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Chronic Phase Who Are Refractory to Imatinib Mesylate (Gleevec)

NCT00042016

TERMINATED Phase 1

Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD

NCT00032773

COMPLETED Phase 1

Study of Rubitecan in Cancer Patients With Renal or Hepatic Dysfunction

NCT00113113

COMPLETED Phase 3

Decitabine Versus Supportive Care in Adults With Advanced-stage MDS

NCT00043381

COMPLETED Phase 2

Nitrocamptothecin in Treating Patients With Locally Recurrent or Metastatic Breast Cancer

NCT00005873

COMPLETED Phase 2

Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomas

NCT00005874

COMPLETED Phase 2

Nitrocamptothecin in Treating Patients With Recurrent Non-small Cell Lung Cancer

NCT00005872

COMPLETED Phase 2

Nitrocamptothecin in Treating Patients With Metastatic Melanoma

NCT00005875

Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 14
Phase 3 5

What the Pipeline for Astex Pharmaceuticals Shows

According to the ClinicalTrials.gov registry, Astex Pharmaceuticals is linked to 38 US clinical trials across every stage of research activity. Of those, 0 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 29 are already marked complete, representing roughly 76% of the total.

The phase mix for Astex Pharmaceuticals reports 5 late-stage studies (Phase 3 and Phase 4 combined) and 32 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Astex Pharmaceuticals is Chronic Myelogenous Leukemia with 1 linked trial, and 4 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.