Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Find a clinical trial that's recruiting now
Search 24,857 actively recruiting US clinical trials by condition, drug, or state, each entry links straight to its NIH ClinicalTrials.gov record so you can check eligibility and contact the study team.
- 24,857
- trials recruiting now
- 14%
- of all US trials open to enrollment
- 52
- states with recruiting sites
A trial is listed as recruiting when its sponsor has marked it open to new participants on the public registry. Type a condition or drug name (for example, "breast cancer" or "pembrolizumab") to narrow the list, and add a state to find studies with a site near you. Results are ordered with the most relevant recruiting studies first; each card shows the study phase and enrollment target, and opens the full record, including eligibility criteria and contact details, on ClinicalTrials.gov.
Popular conditions
50 trials found
Reducing the Risk of Developing Major Depression in Adolescents/Young Adults With Minor Depression/Depression Symptoms
University of Chicago
The purpose of this research study is to assess the feasibility of a combined primary care/web-based depression prevention intervention. Primary care physicians (PCP) currently lack an alternative behaviorally-based approach...
NCT00145951
Physiological and Cognitive Biomarkers for Ketamine's Antidepressant Effects
Massachusetts General Hospital
Anxious depression is a particularly difficult-to-treat subtype of depression. Patients with anxious depression do not respond as well to currently available antidepressant medications. Nevertheless, in previous studies, low dose IV...
NCT02669043
Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression
University of California, Los Angeles
This study will use measurements of depression symptoms and brain activity to determine what factors may influence an individual's response to treatment for depression.
NCT00200902
Testing TRUST Depression Management Intervention
Case Western Reserve University
This study evaluates the effectiveness of a novel depression self-management intervention in adolescents with depression.
NCT03599141
Parent Specific Depression Education and Motivation
University of California, Davis
This project is an investigator-initiated, randomized-controlled trial of the effectiveness of written and verbal parent-specific depression education and motivational advice in increasing participants self-disclosed intention to seek follow...
NCT01453790
Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression
The Cooper Health System
The purpose of this project is to assess the effectiveness of preventative antidepressants immediately following delivery on postpartum depression rates in women at high risk due to prior history of depression or...
NCT02235064
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
Joao L. DeQuevedo
The purpose of this study is to compare the efficacy and side effects magnetic seizure therapy (MST) and electroconvulsive therapy (ECT) in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD).
NCT04080778
Testing the Neuroscience of Guided Learning in Depression
Virginia Polytechnic Institute and State University
Major depression is a prevalent and impairing illness. To better understand the basic science and treatment of depression, the investigators study the behavioral and brain processes associated with learning in depression and...
NCT03203954
Fish Oil for the Treatment of Depression in Patients With Multiple Sclerosis
Oregon Health and Science University
This study will determine whether fish oil can reduce depression in people with multiple sclerosis (MS) who are mild to moderately depressed and are currently taking antidepressant medication. Study hypothesis: Three months...
NCT00122954
Sleep/Wake Cycle and Depression: An Imaging and Treatment Study
Stony Brook University
16.2 million American adults are affected by depression each year. The investigators are studying the relationship between sleep/wake cycle and depression. Mounting evidence suggests that abnormalities in circadian rhythms (biological...
NCT04350567
Cognitive Therapy for Recurrent Depression
University of Texas Southwestern Medical Center
This study determined the effectiveness of continuation phase cognitive therapy versus antidepressant medication in preventing relapse of depression in people with recurrent depression.
NCT00118404
Identification and Therapy of Postpartum Depression
University of Pittsburgh
This study will evaluate the effectiveness of a telephone-based depression screening and care management program in treating depression in postpartum women.
NCT00282776
Primary Care Patients With Depression for Internet-Based Social Support
University of Chicago
The purpose of this study is to develop and pilot test two interventions that lead to at least 30% of individuals with depression presenting to primary care engaging with an Internet-based...
NCT00886730
Mifepristone in Refractory Depression
Stanford University
The purpose of the study is to examine the effectiveness of mifepristone treatment in patients with refractory depression. Refractory depression is defined as clinical depression that is unimproved after treatment with at...
NCT00186056
Treatment Outcome of Vascular Depression
University of Pennsylvania
This 12-week study will evaluate the effectiveness of sertraline (Zoloft®) for treatment of depression associated with small vascular lesions in the brain (vascular depression).
NCT00045773
T- BOOM Teens--Building Options and Opportunities for Moms
University of Pittsburgh
Postpartum depression (PPD) is depression that occurs shortly after the mother delivers her baby. Mothers with postpartum depression may feel sad mood, low motivation or stress; some may have problems caring for...
NCT00745537
Psychosocial Treatment for Women With Depression and Pain
University of Rochester
Patients with depression and pain have poorer outcomes in response to depression treatments than depressed patients without pain. While psychotherapy treatment studies have demonstrated improvement in pain and depression, no psychosocial interventions...
NCT00895999
Assessing Depression in a Geriatric Cancer Population
Memorial Sloan Kettering Cancer Center
The goal of this study is to learn more about how we measure depression in elderly cancer patients (patients aged 70 and older). Depression is one of the most common causes of...
NCT00580476
Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study
University of Minnesota
...The prevalence of depression is three times greater in those with HIV than comparable controls. While antiretroviral therapy (ART) enables immune reconstitution, those with depression do worse clinically than those without depression...
NCT06149624
Effect of Exercise on Perinatal Depression
University of Minnesota
Fifteen percent of women experience depression during pregnancy or postpartum (i.e., perinatal depression). Furthermore, 38% of low income women experience postpartum depression. Given few women with perinatal depression seek treatment, there...
NCT02791932
Vitamin D Supplementation for Bipolar Depression
University of Massachusetts, Worcester
The purpose of this study is to whether vitamin d supplementation in those with low levels may reduce depression symptoms in people experiencing bipolar depression.
NCT01884844
Single IV Dose of GLYX-13 in Patients With Treatment-Resistant Depression
Naurex, Inc, an affiliate of Allergan
The purpose of this study is to determine whether GLYX-13 reduces depression score in patients with treatment-resistant depression.
NCT01234558
Depression Outpatient Cardiology Screening Study
Washington University School of Medicine
This study compares the effects of depression screening and case management to usual care in cardiology outpatients with documented evidence of coronary heart disease. Despite strong evidence that depression is a risk...
NCT01552889
Lamotrigine Therapy in Geriatric Bipolar Depression
Mclean Hospital
We propose to study the efficacy and tolerability of lamotrigine in the treatment of older adults with bipolar depression and to compare measures of brain energy metabolism between older subjects with bipolar...
NCT00720473
Perinatal Depression Treatment in a Pediatric Setting- Pilot Phase
University of Rochester
The purpose of this project is to test whether a new model of collaborative care depression treatment adapted to the needs and preferences of low-income, urban mothers with perinatal depression and...
NCT00804739
Event Related Potentials in Borderline Personality Disorder and Major Depression
State University of New York - Upstate Medical University
This study examines whether depression in people with borderline personality disorder is different than depression in people without borderline personality disorder. Unlike people who have depression alone (i.e. without borderline personality...
NCT01469663
Impact of Depression on Thermoregulation
Penn State University
...and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who are prescribed and taking SNRIs.
NCT06805851
Motivational Interviewing to Reduce Substance Use Among Depression Patients
University of California, San Francisco
The study aims to evaluate the effectiveness of an intervention to reduce alcohol and drug use and depression symptoms, improve functional status and promote appropriate health services utilization, in a sample of...
NCT02420561
Measuring Quality of Decisions About Treatment of Depression
University of Massachusetts, Boston
The purpose of this randomized controlled trial is to examine the impact of a patient decision aid on the quality of decisions about managing symptoms of depression. In particular, we will examine...
NCT01152307
LFMS: Initial Trial in Geriatric Bipolar Depression
Mclean Hospital
The primary aim of this study is to assess the efficacy of Low Field Magnetic Stimulation (LFMS) in treating symptoms of depression and anxiety in older adults suffering from bipolar depression. The...
NCT02707276
Making Decisions About Depression Medications
Victor Montori
The purpose of this study is to determine whether the Depression Medication Choice decision aid is effective in involving patients with depression in making deliberate choices when considering medication treatment.
NCT01502891
Effectiveness of Nimodipine Plus Antidepressant Medication in Treating Vascular Depression
University of Pittsburgh
This study will examine whether combined use of an antidepressant medication and the medication nimodipine reduces risk of depression relapse in patients with vascular depression.
NCT00781326
Omega-3 Fatty Acids for Treatment of Depression in Adolescents
Cedars-Sinai Medical Center
Adolescence is the highest risk period for depression onset. More than 1.3 million youths suffer from major depression annually in the United States, and there is evidence for an increasing trend...
NCT00658476
Comparing Various Treatments for Achieving and Maintaining Remission of Depression
University of Pittsburgh
This study will evaluate the effectiveness of five combinations of drug therapy and psychotherapy in maintaining remission of depression symptoms in people with recurrent major depression.
NCT00227955
Family Cognitive Behavioral Therapy for Preventing Depression in Children
Vanderbilt University
This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression.
NCT00183482
Prevention of Postpartum Depression in Low-Income Women
Butler Hospital
This study will determine whether a prevention program reduces the incidence of postpartum depression in pregnant women who receive public assistance and are at risk for postpartum depression.
NCT00053651
Defining and Treating Depression-related Asthma
State University of New York at Buffalo
...This study will investigate whether children with depression and asthma have less allergic disease and less inflammation than children with asthma who do not have symptoms of depression. The study will also...
NCT04617015
Biological Triggers of Depression in Pregnancy
Michigan State University
The goal of the study is to define and measure biological processes that contribute to the underlying pathophysiologic process of peri-partum depression to be used for identifying those at risk for...
NCT02566980
Stepped Care for Depression in Heart Failure
Washington University School of Medicine
This study evaluates stepped care for depression in patients with heart failure (HF). The stepped care intervention consists of individualized cognitive behavior therapy (CBT). Half of the participants will receive stepped care...
NCT02997865
A Collaborative Care Program to Improve Depression Treatment in Cardiac Patients
Massachusetts General Hospital
...To determine whether a collaborative care depression management program ('Enhanced Care') leads to significantly increased rates of adequate depression treatment compared to usual care (screening and feedback) (Primary Aim). 2. To assess...
NCT00847132
LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLE
University of North Carolina, Chapel Hill
...Targeting depression in patients with SLE may provide benefit to these patients, as there is a clear relationship between chronic pain and depression. The investigators propose that a tACS stimulation montage that...
NCT04141046
Ketogenic Intervention for Bipolar Depression
Mayo Clinic
The purpose of this study is to assess the clinical correlates of therapeutic precision ketosis in bipolar depression and to evaluate the cardiometabolic correlates associated with therapeutic precision ketosis in bipolar depression.
NCT07121894
Detecting Depression and Bipolar Disorder in Adolescents Using a Biomarker Panel
University of Utah
...Teenage depression and bipolar disorder are associated with social isolation, family stress, school failure, substance abuse and suicide. Screening for depression and bipolar disorder so that treatment can be started early in...
NCT01957501
Identifying Biological Markers for Severe Depression
Stanford University
The primary objective of this study is to investigate the biological components of major depression. The investigators are particularity interested in genetic variation and how it contributes to cortisol (because cortisol is...
NCT01831882
Sleep and Healthy Aging Research for Depression (SHARE-D) Study
Michael Irwin, MD
Late-life depression is a significant public health concern, and effective interventions for prevention and treatment are needed. Insomnia and inflammation are modifiable targets for depression prevention, and this study is significant...
NCT03256760
Dosing rTMS for Depression Post-SCI
VA Office of Research and Development
...It has been reported that among Veterans with an SCI, those without depression live longer than those with depression. Thus, depression must be treated appropriately. Repetitive transcranial magnetic stimulation (rTMS) is an...
NCT05553353
Sinusitis and Facial Pain Disorders Anti-Depression Trial
University of Washington
The study hypothesis is that the addition of an antidepressant to the standard treatment regimen in patients with both chronic sinusitis and depression or facial pain disorders and depression will decrease the...
NCT00754793
The Effects of Laughter Therapy on Hemodialysis on Depression
Satellite Healthcare
End stage kidney disease is associated with increased depression. Laughter is associated with improvement in depression in chronic disease. The study objective was to measure the effect of intradialytic group laughter therapy...
NCT04098627
Depression, Experiential Diversity, and Behavioral Novelty
University of Texas at Austin
The purpose of the study is to test whether changes in behavioral patterns are related to changes in depression. Depression is a psychological condition that involves persistent sad mood and/or an...
NCT05767554
Collaborative Care for Depression and Diabetic Retinopathy in African Americans
Thomas Jefferson University
In this feasibility/pilot study, we will develop, refine, and evaluate the feasibility of a novel mental health/ophthalmologic intervention called, "Collaborative Care for Depression and Diabetic Retinopathy" (CC-DDR), which aims...
NCT02121340
Read our methodology - how recruiting status is sourced and refreshed from the public registry.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Recruiting status is reported by each study's sponsor and mirrored from the public registry. Always confirm current eligibility and status on ClinicalTrials.gov before contacting a study.