Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Wolfram Syndrome: early-phase trial registry
1 of 3 indexed Wolfram Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5,224 of 28,963 conditions by registered trial count.
3 US clinical trials · 1 currently recruiting · #5,224 of 28,963 conditions by registered trial count
Wolfram Syndrome: 3 US clinical trials tracked, 1 recruiting.
Wolfram Syndrome is the subject of 3 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 2 of these trials.
Open enrollment, early-phase tilt
Wolfram Syndrome has 3 registered US clinical trials, 1 of them open to new participants right now, about 33% of the total.
- 1
- recruiting participants now
- 33%
- of trials open to enrollment
- 0
- in Phase 3-4 (later-stage)
- 2
- top sponsor: Washington University School of Medicine
Corpus placement: #5,224 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Wolfram Syndrome on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
-
Wolfram Syndrome is recruiting below its size-band peers.
1 of 3 indexed trials (33.3%) are open to enrollment, against a 46.5% average across 28,061 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
Open and recent trials
3 total, page 1 of 1
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study
Washington University School of Medicine
NCT02841553
AMX0035 in Adult Patients With Wolfram Syndrome
Amylyx Pharmaceuticals
NCT05676034
A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome
Washington University School of Medicine
NCT02829268
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Wolfram Syndrome right now
1 recruiting of 3 indexed (33% open).
Phase mix: 0 late (III/IV) vs 2 early (I/II) (early-phase heavy).
Top sponsor: Washington University School of Medicine (2 trials), 1 other listed. 3 shown below, recruiting first. #5,224 of 28,963 conditions by registered trial count.
Why a small condition index still matters
Thin indexes still surface the registry rows that exist for this label. Counts stay small when ClinicalTrials.gov lists few studies under the condition string, not because this page omits rows. Verify any enrollment decision on ClinicalTrials.gov and with a clinician.
Frequently Asked Questions
How many clinical trials are there for Wolfram Syndrome?
PlainTrial tracks 3 US clinical trials for Wolfram Syndrome, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Wolfram Syndrome?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.