Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Undiagnosed Disease clinical trials
2 of 3 indexed Undiagnosed Disease trials are currently recruiting.
Corpus placement: #5,209 of 28,707 conditions by registered trial count.
3 US clinical trials · 2 currently recruiting · #5,209 of 28,707 conditions by registered trial count
Undiagnosed Disease: 3 US clinical trials tracked, 2 recruiting.
Undiagnosed Disease is the subject of 3 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. The most active sponsor is National Human Genome Research Institute (NHGRI), running 1 of these trials.
Enrollment posture brief
Registry condition undiagnosed-disease
OPEN 2 | RECR 67% | LATE 0 | EARLY 0 | RANK #5209 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Acute Hypoxemic Respiratory Failure (67% recruiting · 6 trials)
Undiagnosed Disease lists 2 open slots (67% of 3 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Undiagnosed Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Undiagnosed Disease is recruiting above its size-band peers.
2 of 3 indexed trials (66.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
Open and recent trials
3 total, page 1 of 1
UW Undiagnosed Genetic Diseases Program
University of Wisconsin, Madison
NCT04586075
Exome and Genome Analysis to Elucidate Genetic Etiologies and Population Characteristics in the Plain Community
University of Pittsburgh
NCT02927158
Adult Patients With Undiagnosed Conditions and Their Responses to Clinically Uncertain Results From Exome Sequencing
National Human Genome Research Institute (NHGRI)
NCT03605004
Phase Distribution
Phase data not available
Top Sponsors
Named interventions
Most-linked intervention names on Undiagnosed Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Undiagnosed Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Undiagnosed Disease page
3 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 2 Undiagnosed Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Human Genome Research Institute (NHGRI) sponsors the most Undiagnosed Disease trials on record, review their full trial history before evaluating a specific study. See National Human Genome Research Institute (NHGRI)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Undiagnosed Disease condition card totals 3 registered trials; most-linked intervention Trio Whole Genome Sequencing and Participant-Specific Research; top US site state Wisconsin. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.