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ClinicalTrials.gov 7 recruiting now official registry

Triple Negative Breast Neoplasms clinical trials

7 of 11 indexed Triple Negative Breast Neoplasms trials are currently recruiting.

11 US clinical trials · 7 currently recruiting

Triple Negative Breast Neoplasms is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Seagen, a wholly owned subsidiary of Pfizer, running 2 of these trials.

The research picture

Triple Negative Breast Neoplasms has 11 registered US clinical trials, 7 of them open to new participants right now, about 64% of the total.

7
recruiting participants now
64%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
2
top sponsor: Seagen, a wholly owned subsidiary of Pfizer
Phase 15Phase 22Phase 34

Active & Recent Trials

11 total, page 1 of 1

RECRUITING Phase 3 2,400 participants

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Merck Sharp & Dohme

NCT06966700

RECRUITING Phase 3 1,000 participants

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

Merck Sharp & Dohme

NCT06841354

RECRUITING Phase 1 714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05208762

RECRUITING Phase 1 495 participants

A Study of LY4170156 in Participants With Selected Advanced Solid Tumors

Eli Lilly and Company

NCT06400472

RECRUITING Phase 2 185 participants

Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer

Baylor Breast Care Center

NCT05020860

RECRUITING Phase 2 172 participants

A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT06157892

RECRUITING Phase 1 30 participants

A Study of Pembrolizumab and Cryoablation in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT06246968

ACTIVE NOT RECRUITING Phase 3 923 participants

Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC

AstraZeneca

NCT03997123

ACTIVE NOT RECRUITING Phase 1 329 participants

Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies

BicycleTx Limited

NCT04561362

ACTIVE NOT RECRUITING Phase 1 243 participants

A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer

AstraZeneca

NCT03742102

ACTIVE NOT RECRUITING Phase 3 137 participants

Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss

Novartis Pharmaceuticals

NCT04251533

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 2
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Triple Negative Breast Neoplasms Trial Landscape

11 indexed Triple Negative Breast Neoplasms studies · 7 recruiting (64%).

Phase mix: 4 late (III/IV) vs 7 early (I/II).

Top sponsor: Seagen, a wholly owned subsidiary of Pfizer (2 trials), 7 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Triple Negative Breast Neoplasms?

PlainTrial tracks 11 US clinical trials for Triple Negative Breast Neoplasms, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Triple Negative Breast Neoplasms?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.