Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Syphilis: early-phase trial registry
3 of 7 indexed Syphilis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,497 of 28,707 conditions by registered trial count.
7 US clinical trials · 3 currently recruiting · #2,497 of 28,707 conditions by registered trial count
Syphilis: 7 US clinical trials tracked, 3 recruiting.
Syphilis is the subject of 7 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is University of Southern California, running 2 of these trials.
Enrollment posture brief
Registry condition syphilis
OPEN 3 | RECR 43% | LATE 1 | EARLY 2 | RANK #2497 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Adrenoleukodystrophy (43% recruiting · 7 trials)
Syphilis lists 3 open slots (43% of 7 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Syphilis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Syphilis is recruiting below its size-band peers.
3 of 7 indexed trials (42.9%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Syphilis research.
University of Southern California accounts for 2 of 7 trials (28.6%). 6 distinct sponsors appear on at least one study for this condition label.
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Typical Syphilis enrolment sits around 75 participants.
Median target enrolment is 75 among the 7 trials that report a genuine target (sentinel values excluded). 4 of those (57.1%) plan for fewer than 100 participants.
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Syphilis research is mostly interventional.
7 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
7 total, page 1 of 1
Modernizing Perinatal Syphilis Testing
The University of Texas Health Science Center, Houston
NCT06082453
Cefixime Clinical Trial
University of Southern California
NCT04958122
Daily Doxycycline for Early Syphillis
University of Washington
NCT06683638
Linezolid for Syphilis Pilot Study
University of Southern California
NCT05548426
Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission
Jacobi Medical Center
NCT00553111
Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening
University of Michigan
NCT06100250
mLab App Plus: A Randomized Controlled Trial of a Mobile Health (mHealth) Intervention
Columbia University
NCT06059443
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Syphilis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Syphilis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Syphilis page
7 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 Syphilis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Southern California sponsors the most Syphilis trials on record, review their full trial history before evaluating a specific study. See University of Southern California's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Syphilis condition card totals 7 registered trials; most-linked intervention mLab App Plus; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.