Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06683638 · ClinicalTrials.gov registry record · Phase 2
Daily Doxycycline for Early Syphillis
A Phase 2 study of Syphilis, sponsored by University of Washington.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT06683638 is a Phase 2 study of Syphilis that is actively recruiting participants, run by University of Washington. The registered enrollment target is 15 participants, below the 272-participant average among 6 other Syphilis trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06683638, a Phase 2 study of Syphilis, is actively recruiting participants, sponsored by University of Washington.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn if doxycycline taken as 200mg daily for 14 days is effective to treat early stage syphilis. This is different from how doxycycline is typically used for syphilis because the full doxycycline dose will be taken at the same time of day, rather than split up into a twice daily regimen. Lab data support that taking the medication as a single daily dose should be effective as treatment, but it has not been studied clinically. The main question this study aims to answer is: Is doxycycline taken as a single daily dose of 200mg for 14 days an effective treatment for early syphilis based on a combined outcome of clinical improvement and blood test improvement? Participants will: 1. Take doxycycline 200mg daily for 14 days 2. Submit oral and rectal swabs that test for syphilis bacteria every other day for 2 weeks, returned by mail 3. Complete 2 brief online surveys over the first 2 weeks 4. Return to the clinic for an interview and blood draw every 3 months for a maximum of 3 study visits, including the first visit The investigators will compare the percentage of participants in the study who have response to treatment by 6 months to that of persons who have received standard (CDC-recommended) regimens. To do this, the investigators will calculate response percentage estimates following a shot of long-acting penicillin or 14 days of doxycycline 100mg twice daily from 60-person samples from the sexual health program's records.
Conditions Studied
Interventions
- DRUG Doxycycline 200mg daily for 14 days
Study Locations (1)
Washington
- Public Health Sexual Health Clinic - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2025-03-03 |
| Est. Completion | 2026-06-26 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06683638
The ClinicalTrials.gov registry entry for NCT06683638 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 272-participant average among 6 other Syphilis trials with a reported enrollment target (94% lower). The listed sponsor is University of Washington, which has 1,048 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Syphilis appearing as the primary indexed condition, and to 1 intervention - of which Doxycycline 200mg daily for 14 days is the first listed.
NCT06683638 reports 1 study location spanning 1 distinct geographic area - top geographies include Washington.
Frequently Asked Questions
What is clinical trial NCT06683638 about?
NCT06683638 is a clinical study titled "Daily Doxycycline for Early Syphillis". The goal of this clinical trial is to learn if doxycycline taken as 200mg daily for 14 days is effective to treat early stage syphilis. This is different from how doxycycline is typically used for syphilis because the full doxycycline dose will be taken at the same time of day, rather than split up ...
What is the current status of trial NCT06683638?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 15 participants. The study started on 2025-03-03. Estimated completion is 2026-06-26.
What conditions does trial NCT06683638 study?
This clinical trial studies the following conditions: Syphilis.
What interventions are being tested in trial NCT06683638?
The interventions under investigation include: Doxycycline 200mg daily for 14 days (DRUG).
Who is sponsoring clinical trial NCT06683638?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06683638 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Syphilis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Linezolid for Syphilis Pilot Study
ACTIVE NOT RECRUITING · Phase 2
-
Cefixime Clinical Trial
RECRUITING · Phase 3
-
Modernizing Perinatal Syphilis Testing
RECRUITING · NA
-
Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening
COMPLETED · NA
-
Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission
COMPLETED · NA
-
mLab App Plus: A Randomized Controlled Trial of a Mobile Health (mHealth) Intervention
COMPLETED · NA
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.