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ClinicalTrials.gov 2 recruiting now early-phase tilt small index

Stage IV Breast Cancer AJCC v6 and v7: early-phase trial registry

2 of 15 indexed Stage IV Breast Cancer AJCC v6 and v7 trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,140 of 28,707 conditions by registered trial count.

15 US clinical trials · 2 currently recruiting · #1,140 of 28,707 conditions by registered trial count

Stage IV Breast Cancer AJCC v6 and v7: 15 US clinical trials tracked, 2 recruiting.

Stage IV Breast Cancer AJCC v6 and v7 is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 8 of these trials.

Enrollment posture brief

Registry condition stage-iv-breast-cancer-ajcc-v6-and-v7

OPEN 2 | RECR 13% | LATE 2 | EARLY 12 | RANK #1140 | SPON 8

Nearest open-share peer: Drug Addiction (13% recruiting · 15 trials)

Advanced Lung Non-Small Cell53.3%AIDS26.7%Stage IV Breast Cancer A (th…13%Adult Acute Myeloid Leukemia0%Adult Glioblastoma0%
Open-enrollment share among volume-matched conditions near Stage IV Breast Cancer AJCC v6 and v7

Stage IV Breast Cancer AJCC v6 and v7 lists 2 open slots (13% of 15 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Stage IV Breast Cancer AJCC v6 and v7 on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Stage IV Breast Cancer AJCC v6 and v7 is recruiting below its size-band peers.

    2 of 15 indexed trials (13.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Stage IV Breast Cancer AJCC v6 and v7 research.

    National Cancer Institute (NCI) accounts for 8 of 15 trials (53.3%). 5 distinct sponsors appear on at least one study for this condition label.

  3. Most Stage IV Breast Cancer AJCC v6 and v7 trials plan to enrol fewer than 100 people.

    Median target enrolment is 54 among the 15 trials that report a genuine target (sentinel values excluded). 13 of those (86.7%) plan for fewer than 100 participants.

  4. Stage IV Breast Cancer AJCC v6 and v7 research is mostly interventional.

    14 interventional and 1 observational studies make up this index (93.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 27Phase 32

Open and recent trials

15 total, page 1 of 1

RECRUITING Phase 3 491 participants

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

SWOG Cancer Research Network

NCT03418961

RECRUITING Phase 1 54 participants

A Vaccine (MV-s-NAP) for the Treatment of Patients With Invasive Metastatic Breast Cancer

Mayo Clinic

NCT04521764

ACTIVE NOT RECRUITING Phase 2 99 participants

FES PET/CT in Predicting Response in Patients With Newly Diagnosed Metastatic Breast Cancer Receiving Endocrine Therapy

National Cancer Institute (NCI)

NCT02398773

ACTIVE NOT RECRUITING Phase 2 81 participants

Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer

National Cancer Institute (NCI)

NCT02311933

ACTIVE NOT RECRUITING 68 participants

Genetic Analysis in Blood and Tumor Samples From Patients With Advanced or Metastatic Estrogen Receptor Positive and HER2 Negative Breast Cancer Receiving Palbociclib and Endocrine Therapy

Mayo Clinic

NCT03281902

ACTIVE NOT RECRUITING Phase 1 62 participants

Z-Endoxifen Hydrochloride in Treating Patients With Metastatic or Locally Recurrent Estrogen Receptor-Positive Breast Cancer

National Cancer Institute (NCI)

NCT01327781

ACTIVE NOT RECRUITING Phase 2 47 participants

Pembrolizumab, Endocrine Therapy, and Palbociclib in Treating Postmenopausal Patients With Newly Diagnosed Metastatic Stage IV Estrogen Receptor Positive Breast Cancer

City of Hope Medical Center

NCT02778685

ACTIVE NOT RECRUITING Phase 1 44 participants

Veliparib and Carboplatin in Treating Patients With HER2-Negative Metastatic Breast Cancer

National Cancer Institute (NCI)

NCT01251874

ACTIVE NOT RECRUITING Phase 2 40 participants

Nab-Paclitaxel in Treating Older Patients With Locally Advanced or Metastatic Breast Cancer

City of Hope Medical Center

NCT01463072

ACTIVE NOT RECRUITING Phase 1 35 participants

Cyclophosphamide and Veliparib in Treating Patients With Locally Advanced or Metastatic Breast Cancer

National Cancer Institute (NCI)

NCT01351909

ACTIVE NOT RECRUITING Phase 2 2 participants

Serial FES PET/CT to Measure Hormone Expression in Patients Undergoing Endocrine Targeted Therapy

University of Washington

NCT04692103

COMPLETED Phase 3 799 participants

Paclitaxel, Nab-paclitaxel, or Ixabepilone With or Without Bevacizumab in Treating Patients With Stage IIIC or Stage IV Breast Cancer

National Cancer Institute (NCI)

NCT00785291

COMPLETED Phase 2 58 participants

Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer

National Cancer Institute (NCI)

NCT01349959

COMPLETED Phase 1 40 participants

Dinaciclib and Epirubicin Hydrochloride in Treating Patients With Metastatic Triple-Negative Breast Cancer

National Cancer Institute (NCI)

NCT01624441

COMPLETED Phase 2 2 participants

Ribociclib and Aromatase Inhibitor in Treating Older Participants With Hormone Receptor Positive Metastatic Breast Cancer

City of Hope Medical Center

NCT03477396

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 7
Phase 3 2

Named interventions

Most-linked intervention names on Stage IV Breast Cancer AJCC v6 and v7 records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Laboratory Biomarker Analysis Other
12 trials
Computed Tomography Procedure
4 trials
Pharmacological Study Other
3 trials
Questionnaire Administration Other
3 trials
Positron Emission Tomography Procedure
3 trials
Biospecimen Collection Procedure
3 trials
Endoxifen Hydrochloride Drug
2 trials
F-18 16 Alpha-Fluoroestradiol Drug
2 trials

US sites by state

Facility locations filed on Stage IV Breast Cancer AJCC v6 and v7 trials. A trial with sites in several states counts in each.

California 8 trials
Minnesota 5 trials
New York 4 trials
Arizona 4 trials
Ohio 3 trials
Arkansas 3 trials
Washington 2 trials
Texas 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Stage IV Breast Cancer AJCC v6 and v7 page

15 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Stage IV Breast Cancer AJCC v6 and v7 condition card totals 15 registered trials; most-linked intervention Laboratory Biomarker Analysis; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.