Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Smith-Lemli-Opitz Syndrome: early-phase trial registry
2 of 5 indexed Smith-Lemli-Opitz Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #3,391 of 28,707 conditions by registered trial count.
5 US clinical trials · 2 currently recruiting · #3,391 of 28,707 conditions by registered trial count
Smith-Lemli-Opitz Syndrome: 5 US clinical trials tracked, 2 recruiting.
Smith-Lemli-Opitz Syndrome is the subject of 5 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), running 3 of these trials.
Enrollment posture brief
Registry condition smith-lemli-opitz-syndrome
OPEN 2 | RECR 40% | LATE 0 | EARLY 2 | RANK #3391 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Achondroplasia (40% recruiting · 10 trials)
Smith-Lemli-Opitz Syndrome lists 2 open slots (40% of 5 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Smith-Lemli-Opitz Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Smith-Lemli-Opitz Syndrome is recruiting below its size-band peers.
2 of 5 indexed trials (40%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Smith-Lemli-Opitz Syndrome research.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) accounts for 3 of 5 trials (60%). 3 distinct sponsors appear on at least one study for this condition label.
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Typical Smith-Lemli-Opitz Syndrome enrolment sits around 130 participants.
Median target enrolment is 130 among the 5 trials that report a genuine target (sentinel values excluded). 1 of those (20%) plan for fewer than 100 participants.
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Smith-Lemli-Opitz Syndrome research leans observational.
2 interventional and 3 observational studies make up this index (40% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
5 total, page 1 of 1
Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT05047354
Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)
University of Colorado, Denver
NCT01773278
Estimation of the Carrier Frequency and Incidence of Smith-Lemli-Opitz Syndrome in African Americans
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00017732
Study of Smith-Lemli-Opitz Syndrome
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00001721
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
Forbes Porter, M.D.
NCT00064792
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Smith-Lemli-Opitz Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Smith-Lemli-Opitz Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Smith-Lemli-Opitz Syndrome page
5 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 2 Smith-Lemli-Opitz Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) sponsors the most Smith-Lemli-Opitz Syndrome trials on record, review their full trial history before evaluating a specific study. See Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Smith-Lemli-Opitz Syndrome condition card totals 5 registered trials; most-linked intervention Cholesterol; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.