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ClinicalTrials.gov 2 recruiting now early-phase tilt small index

Recurrent Ewing Sarcoma: early-phase trial registry

2 of 10 indexed Recurrent Ewing Sarcoma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,724 of 28,707 conditions by registered trial count.

10 US clinical trials · 2 currently recruiting · #1,724 of 28,707 conditions by registered trial count

Recurrent Ewing Sarcoma: 10 US clinical trials tracked, 2 recruiting.

Recurrent Ewing Sarcoma is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 7 of these trials.

Enrollment posture brief

Registry condition recurrent-ewing-sarcoma

OPEN 2 | RECR 20% | LATE 0 | EARLY 10 | RANK #1724 | SPON 7

Nearest open-share peer: Acral Lentiginous Melanoma (20% recruiting · 5 trials)

Acute Leukemia of Ambiguous 80%Achondroplasia40%Accelerated Phase Chronic My20%Accidental Fall20%Recurrent Ewing Sarcoma (thi…20%
Open-enrollment share among volume-matched conditions near Recurrent Ewing Sarcoma

Recurrent Ewing Sarcoma lists 2 open slots (20% of 10 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Recurrent Ewing Sarcoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Recurrent Ewing Sarcoma is recruiting below its size-band peers.

    2 of 10 indexed trials (20%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Recurrent Ewing Sarcoma research.

    National Cancer Institute (NCI) accounts for 7 of 10 trials (70%). 3 distinct sponsors appear on at least one study for this condition label.

  3. Most Recurrent Ewing Sarcoma trials plan to enrol fewer than 100 people.

    Median target enrolment is 31 among the 10 trials that report a genuine target (sentinel values excluded). 8 of those (80%) plan for fewer than 100 participants.

  4. Recurrent Ewing Sarcoma research is mostly interventional.

    10 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 13Phase 27

Open and recent trials

10 total, page 1 of 1

RECRUITING Phase 1 147 participants

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Children's Oncology Group

NCT04851119

RECRUITING Phase 1 90 participants

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

St. Jude Children's Research Hospital

NCT04901702

ACTIVE NOT RECRUITING Phase 2 1,376 participants

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

National Cancer Institute (NCI)

NCT03155620

ACTIVE NOT RECRUITING Phase 1 31 participants

Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors

National Cancer Institute (NCI)

NCT05071209

ACTIVE NOT RECRUITING Phase 2 20 participants

Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03698994

ACTIVE NOT RECRUITING Phase 2 5 participants

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial

National Cancer Institute (NCI)

NCT04284774

ACTIVE NOT RECRUITING Phase 2 3 participants

Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT04195555

ACTIVE NOT RECRUITING Phase 2 1 participants

Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial

National Cancer Institute (NCI)

NCT04320888

COMPLETED Phase 2 50 participants

Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors

Children's Oncology Group

NCT00070109

COMPLETED Phase 2 23 participants

Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03526250

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 7

Named interventions

Most-linked intervention names on Recurrent Ewing Sarcoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Computed Tomography Procedure
2 trials
Biospecimen Collection Procedure
2 trials
trabectedin Drug
1 trials
Elimusertib Drug
1 trials
Radionuclide Imaging Procedure
1 trials
Pharmacological Study Other
1 trials
pharmacological study Other
1 trials
Onivyde Drug
1 trials

US sites by state

Facility locations filed on Recurrent Ewing Sarcoma trials. A trial with sites in several states counts in each.

California 10 trials
Alabama 8 trials
Arkansas 7 trials
Arizona 6 trials
Alaska 6 trials
Colorado 5 trials
Tennessee 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Recurrent Ewing Sarcoma page

10 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Recurrent Ewing Sarcoma condition card totals 10 registered trials; most-linked intervention Computed Tomography; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.