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ClinicalTrials.gov 4 recruiting now official registry

Prognostic Stage IV Breast Cancer AJCC v8 clinical trials

4 of 10 indexed Prognostic Stage IV Breast Cancer AJCC v8 trials are currently recruiting.

10 US clinical trials · 4 currently recruiting

Prognostic Stage IV Breast Cancer AJCC v8 is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Roswell Park Cancer Institute, running 2 of these trials.

The research picture

Prognostic Stage IV Breast Cancer AJCC v8 has 10 registered US clinical trials, 4 of them open to new participants right now, about 40% of the total.

4
recruiting participants now
40%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Roswell Park Cancer Institute
Phase 12Phase 25

Active & Recent Trials

10 total, page 1 of 1

RECRUITING NA 739 participants

S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

SWOG Cancer Research Network

NCT03723928

RECRUITING 700 participants

Biomarkers and Clinical Features of Metastatic Breast Cancer in Patients Treated With CDK4/6 Inhibitors

Roswell Park Cancer Institute

NCT04526587

RECRUITING Phase 2 43 participants

Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

City of Hope Medical Center

NCT04305834

RECRUITING Phase 2 23 participants

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Roswell Park Cancer Institute

NCT04348747

ACTIVE NOT RECRUITING NA 243 participants

A Video Intervention to Improve Patient Understanding of Tumor Genomic Testing in Patients With Metastatic Cancer

Ohio State University Comprehensive Cancer Center

NCT05215769

ACTIVE NOT RECRUITING Phase 2 138 participants

Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study

ECOG-ACRIN Cancer Research Group

NCT04316117

ACTIVE NOT RECRUITING Phase 2 44 participants

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

SWOG Cancer Research Network

NCT04647916

ACTIVE NOT RECRUITING Phase 2 25 participants

INCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE Study

Mridula George, MD

NCT04445844

ACTIVE NOT RECRUITING Phase 1 14 participants

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

University of Southern California

NCT04616248

ACTIVE NOT RECRUITING Phase 1 9 participants

CF33-hNIS-antiPDL1 for the Treatment of Metastatic Triple Negative Breast Cancer

City of Hope Medical Center

NCT05081492

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Prognostic Stage IV Breast Cancer AJCC v8 Trial Landscape

10 indexed Prognostic Stage IV Breast Cancer AJCC v8 studies · 4 recruiting (40%).

Phase mix: 0 late (III/IV) vs 7 early (I/II).

Top sponsor: Roswell Park Cancer Institute (2 trials), 6 others listed. 10 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Prognostic Stage IV Breast Cancer AJCC v8?

PlainTrial tracks 10 US clinical trials for Prognostic Stage IV Breast Cancer AJCC v8, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Prognostic Stage IV Breast Cancer AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.